Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker

Several studies have reported conflicting results regarding correlations of the loss of Fhit expression with clinicopathological parameters in gastric cancer. We investigated the immunohistochemical expression of Fhit in 362 cases of sporadic advanced gastric adenocarcinoma. The series included 64 c...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2006, Vol.132 (1), p.45-50
Main Authors: BRAGANTINI, Emma, BARBI, Stefano, BEGHELLI, Stefania, MOORE, Patrick S, DE MANZONI, Giovanni, ROVIELLO, Franco, TOMEZZOLI, Anna, VINDIGNI, Carla, BAFFA, Raffaele, SCARPA, Aldo
Format: Article
Language:English
Subjects:
Acid Anhydride Hydrolases - analysis
Acid Anhydride Hydrolases - immunology
Aged
Analysis of Variance
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - analysis
Cancer
Down-Regulation
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Italy - epidemiology
Lymphatic Metastasis
Male
Medical sciences
Microsatellite Repeats
Middle Aged
Neoplasm Proteins - analysis
Neoplasm Proteins - immunology
Neoplasm Staging
Pharmacology. Drug treatments
Predictive Value of Tests
Prognosis
Stomach
Stomach Neoplasms - chemistry
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumors
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Summary:Several studies have reported conflicting results regarding correlations of the loss of Fhit expression with clinicopathological parameters in gastric cancer. We investigated the immunohistochemical expression of Fhit in 362 cases of sporadic advanced gastric adenocarcinoma. The series included 64 cases with microsatellite instability associated with defective mismatch repair genes. Fhit expression resulted absent in 72% of the tumors analyzed. Absence of Fhit expression was more frequent in cases with diffuse and mixed histotype compared to the intestinal histotype (P=0.009). Absence of Fhit expression also correlated with tumor stage (P
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-005-0045-9