A variant chronic B-cell lymphoma characterized by villous cells with novel immunophenotypic and cytogenetic profiles

The less common chronic B-cell lymphomas include hairy cell leukemia, hairy cell leukemia variant and splenic lymphoma with villous lymphocytes. These disease entities can sometimes cause a diagnostic dilemma; however, immunophenotypic markers have been identified as disease specific and scoring sys...

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Bibliographic Details
Published in:Leukemia & lymphoma 2006, Vol.47 (1), p.129-134
Main Authors: Coupland, L. A., Brun, M., Jammu, V., D'Rozario, J. M.
Format: Article
Language:English
Subjects:
Cell Surface Extensions - pathology
Chronic Disease
Cytogenetic Analysis - methods
Gene Expression Profiling
Genetic Variation
Humans
Immunophenotyping
Lymphoma, B-Cell - diagnosis
Lymphoma, B-Cell - genetics
Lymphoma, B-Cell - pathology
Male
Middle Aged
Sensitivity and Specificity
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Description
Summary:The less common chronic B-cell lymphomas include hairy cell leukemia, hairy cell leukemia variant and splenic lymphoma with villous lymphocytes. These disease entities can sometimes cause a diagnostic dilemma; however, immunophenotypic markers have been identified as disease specific and scoring systems have been proposed to assist the process. This study reports a case of a chronic B-cell lymphoma with long cytoplasmic projections which does not fit into any of the published disease categories based upon a combination of clinical and morphological features and immunophenotyping. Furthermore, this case featured a combination of cytogenetic abnormalities not previously described in the published literature in association with a B-cell lymphoproliferative disorder.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190500277126