Aquaporin 1 expression in cystic hemangioblastomas

Hemangioblastomas of the central nervous system (CNS) become clinically manifest through the development of huge associated cysts. The mechanism underlying these fluid collections is as yet largely unexplained. Aquaporins (AQPs) are cell proteins responsible for transmembrane water transport that ha...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2006-01, Vol.392 (3), p.178-180
Main Authors: Longatti, Pierluigi, Basaldella, Luca, Orvieto, Enrico, Tos, Angelo Paolo Dei, Martinuzzi, Andrea
Format: Article
Language:English
Subjects:
Adult
Aged
AQP1
Aquaporin 1 - metabolism
Aquaporins
Biological and medical sciences
Cerebellar Neoplasms - metabolism
Cerebellar Neoplasms - pathology
Cerebrospinal fluid. Meninges. Spinal cord
Cyst
Cysts
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic - physiology
Hemangioblastoma
Hemangioblastoma - metabolism
Hemangioblastoma - pathology
Humans
Hydrocephalus
Immunohistochemistry - methods
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Vertebrates: nervous system and sense organs
von Hippel-Lindau
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hemangioblastomas of the central nervous system (CNS) become clinically manifest through the development of huge associated cysts. The mechanism underlying these fluid collections is as yet largely unexplained. Aquaporins (AQPs) are cell proteins responsible for transmembrane water transport that have been extensively studied in the last 10 years. We analyzed AQP1 water channel expression by an immunostaining technique in ten specimens of operated cerebellar cystic hemangioblastomas, for which complete clinical and follow-up records were available. Tumour and associated cyst volumes were determined by neuroimaging and then compared with immunohistochemical scores. Stromal cancer cells showed surprisingly high AQP1 expression, and huge cyst volume development showed correlation with higher immunostaining scores. Heavy AQP1 expression in cystic hemangioblastomas could shed new light on the mechanisms of satellite cyst development.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.09.083