Familial Mediterranean Fever-Related Nephrotic Syndrome and Successful Full-Term Pregnancy

Familial Mediterranean fever (FMF) is a systemic disease with an autosomal recessive inheritance. The most serious complication of FMF is renal amyloidosis. Pregnancy may adversely affect renal function in FMF patients with amyloidosis and nephrotic syndrome. A 20-year-old woman with FMF related nep...

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Bibliographic Details
Published in:Archives of medical research 2006, Vol.37 (1), p.178-180
Main Authors: Tutuncu, Levent, Atasoyu, Enes Murat, Evrenkaya, Rifki, Mungen, Ercument
Format: Article
Language:English
Subjects:
Amyloidosis
Colchicine - administration & dosage
Familial Mediterranean fever
Familial Mediterranean Fever - complications
Familial Mediterranean Fever - drug therapy
Female
Gout Suppressants - administration & dosage
Humans
Live Birth
Nephrotic syndrome
Nephrotic Syndrome - complications
Nephrotic Syndrome - drug therapy
Pregnancy
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Summary:Familial Mediterranean fever (FMF) is a systemic disease with an autosomal recessive inheritance. The most serious complication of FMF is renal amyloidosis. Pregnancy may adversely affect renal function in FMF patients with amyloidosis and nephrotic syndrome. A 20-year-old woman with FMF related nephrotic syndrome became pregnant while receiving colchicine therapy. Colchicine treatment was continued during pregnancy with close observation. She gave birth to a 2400 g healthy female newborn at the 38th week of gestation. Pregnancy and neonatal outcome were uneventful. It is advisable to continue colchicine treatment during conception and pregnancy in FMF patients with amyloid related nephrotic syndrome. Colchicine treatment with bed rest, protein reinforcement, acetylsalicylic acid administration and close follow-up may improve the outcome of pregnancy in FMF patients.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2005.04.013