Increased Serum Levels of Soluble CD30 in Patients with Common Variable Immunodeficiency and Its Clinical Implications

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were inves...

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Bibliographic Details
Published in:Journal of clinical immunology 2008, Vol.28 (1), p.78-84
Main Authors: Rezaei, Nima, Haji-Molla-Hoseini, Mostafa, Aghamohammadi, Asghar, Pourfathollah, Ali Akbar, Moghtadaie, Mina, Pourpak, Zahra
Format: Article
Language:English
Subjects:
Adolescent
Adult
B-Lymphocyte Subsets
Biomedical and Life Sciences
Biomedicine
Child
Child, Preschool
Common Variable Immunodeficiency - blood
Common Variable Immunodeficiency - immunology
Female
Humans
Immunoglobulins - blood
Immunology
Infectious Diseases
Internal Medicine
Ki-1 Antigen - blood
Lymphocyte Count
Male
Medical Microbiology
Middle Aged
T-Lymphocyte Subsets
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Summary:Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent pyogenic infections, autoimmunity, and malignancies. Twenty-five cases with CVID (18 male and 7 female) and 25 healthy volunteers were investigate in this study. Soluble CD30 (sCD30) serum levels of the subjects were measured and compared. Serum levels of sCD30 in the patients with CVID were significantly increased in comparison with controls (36.93 ± 32.38 vs 5.27 ± 1.32 U/ml, P  
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-007-9135-6