Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis

Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biolog...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2008-02, Vol.21 (1), p.1-6
Main Authors: Ide, Hisamitsu, Hatake, Kiyohiko, Terado, Yuichi, Tsukino, Hiroyuki, Okegawa, Takatsugu, Nutahara, Kikuo, Higashihara, Eiji, Horie, Shigeo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - secondary
Aged
Biomarkers, Tumor - analysis
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Bone cancer
bone metastasis
Bone Neoplasms - secondary
Cell Biology
Colonies
Colony-stimulating factor
Disease Progression
Gynecology
Humans
Immunohistochemistry
Life Sciences
Macrophage colony-stimulating factor
Macrophage Colony-Stimulating Factor - analysis
Macrophage Colony-Stimulating Factor - antagonists & inhibitors
Macrophage Colony-Stimulating Factor - blood
Macrophage Colony-Stimulating Factor - physiology
Male
Metastases
Metastasis
Middle Aged
Oncology
Patients
Prostate cancer
Prostatic Neoplasms - etiology
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Reproductive Medicine
Research Article
Serum levels
Stem Cells
Surgery
Tumors
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Summary:Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.
ISSN:0914-7470
1749-0774
DOI:10.1111/j.1749-0774.2007.00042.x