Siglecs--the major subfamily of I-type lectins

Animal glycan-recognizing proteins can be broadly classified into two groups--lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfated glycosaminoglycan (SGAG)-binding proteins (which appear to have evolved by convergent evolution). Proteins ot...

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Bibliographic Details
Published in:Glycobiology (Oxford) 2006, Vol.16 (1), p.1R-27R
Main Authors: Varki, Ajit, Angata, Takashi
Format: Article
Language:English
Subjects:
5-N-glycolylneuraminic acid
5‐N-acetylneuraminic acid
Animals
B-cell receptor
BCR
Cell Communication - physiology
central nervous system
cluster of differentiation antigen
CNS
EST
evolution
Evolution, Molecular
expressed sequence tag
Fuc
fucose
Gal
galactose
Humans
IgSF
immunoglobulin superfamily
immunoreceptor tyrosine-based inhibitory motif
ITIM
lectins
Lectins - metabolism
lipopolysaccharide
LPS
MAG
myelin-associated glycoprotein
natural killer
Neu5Ac
Neu5Gc
P-selection glycoprotein ligand
peripheral nervous system
PNS
Polysaccharides - metabolism
Protein Binding - physiology
protein tyrosine phosphatase
PSGL
PTP
Schwann cell myelin protein
SGAG
Sia
sialic acid
Sialic Acid Binding Immunoglobulin-like Lectins
sialic acids
Sialic Acids - metabolism
sialoadhesin
Siglecs
SMP
sulfated glycosaminoglycan
type unspecified
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Description
Summary:Animal glycan-recognizing proteins can be broadly classified into two groups--lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfated glycosaminoglycan (SGAG)-binding proteins (which appear to have evolved by convergent evolution). Proteins other than antibodies and T-cell receptors that mediate glycan recognition via immunoglobulin (Ig)-like domains are called "I-type lectins." The major homologous subfamily of I-type lectins with sialic acid (Sia)-binding properties and characteristic amino-terminal structural features are called the "Siglecs" (Sia-recognizing Ig-superfamily lectins). The Siglecs can be divided into two groups: an evolutionarily conserved subgroup (Siglecs-1, -2, and -4) and a CD33/Siglec-3-related subgroup (Siglecs-3 and -5-13 in primates), which appear to be rapidly evolving. This article provides an overview of historical and current information about the Siglecs.
ISSN:0959-6658
1460-2423
DOI:10.1093/glycob/cwj008