Understanding the multiple functions of Gr-1+ cell subpopulations during microbial infection

The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1 + monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicate the i...

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Bibliographic Details
Published in:Immunologic research 2008-01, Vol.40 (1), p.35-48
Main Authors: Egan, Charlotte E., Sukhumavasi, Woraporn, Bierly, Allison L., Denkers, Eric Y.
Format: Article
Language:English
Subjects:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Cells
Communicable Diseases - immunology
Dendritic Cells - immunology
Immunity, Innate - immunology
Immunology
Infections
Internal Medicine
Medicine/Public Health
Mice
Monocytes - immunology
Neutrophils - immunology
Pathogens
Receptors, CCR2 - immunology
Receptors, Chemokine - immunology
Studies
Toxoplasmosis - immunology
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Summary:The murine cell surface determinant Gr-1 is expressed at high level on neutrophils. Depletion of polymorphonuclear leukocytes with anti-Gr-1 + monoclonal antibody results in increased susceptibility and dysregulated immunity to many microbial pathogens, a finding widely interpreted to indicate the importance of neutrophils during infection. Yet, in recent years it has become clear that additional cell types express the Gr-1 determinant, including dendritic cell and monocyte subpopulations. In this review, we evaluate current knowledge on the functional aspects of Gr-1 + cell populations. We focus on infection with the opportunistic protozoan Toxoplasma gondii , a case where host survival depends on an intact Gr-1 + cell population.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-007-0061-8