Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

A novel series of trisubstituted benzimidazole and its precursors ( 3– 7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed tha...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008, Vol.18 (1), p.432-435
Main Authors: Thimmegowda, N.R., Nanjunda Swamy, S., Ananda Kumar, C.S., Sunil Kumar, Y.C., Chandrappa, S., Yip, George W., Rangappa, K.S.
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Benzimidazoles - chemical synthesis
Benzimidazoles - chemistry
Benzimidazoles - pharmacology
Biological and medical sciences
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cell Growth Processes - drug effects
Cell Line, Tumor
Cell proliferation
General aspects
Humans
MDA-MB-231
Medical sciences
Nuclear Magnetic Resonance, Biomolecular
Pharmacology. Drug treatments
Spectroscopy, Fourier Transform Infrared
Trisubstituted benzimidazole
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Summary:A novel series of trisubstituted benzimidazole and its precursors ( 3– 7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide ( 3) was the potent inhibitor.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2007.08.078