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Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation
A novel series of trisubstituted benzimidazole and its precursors ( 3– 7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed tha...
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| Published in: | Bioorganic & medicinal chemistry 2008, Vol.18 (1), p.432-435 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c415t-fb4dd47cac9cb8d034d2094dfe5d2f09b79d2141f817844c193ba227a5ce9a393 |
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| cites | cdi_FETCH-LOGICAL-c415t-fb4dd47cac9cb8d034d2094dfe5d2f09b79d2141f817844c193ba227a5ce9a393 |
| container_end_page | 435 |
| container_issue | 1 |
| container_start_page | 432 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 18 |
| creator | Thimmegowda, N.R. Nanjunda Swamy, S. Ananda Kumar, C.S. Sunil Kumar, Y.C. Chandrappa, S. Yip, George W. Rangappa, K.S. |
| description | A novel series of trisubstituted benzimidazole and its precursors (
3–
7) were synthesised and characterized by using
1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound
N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (
3) was the potent inhibitor. |
| doi_str_mv | 10.1016/j.bmcl.2007.08.078 |
| format | article |
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3–
7) were synthesised and characterized by using
1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound
N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (
3) was the potent inhibitor.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3405</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmcl.2007.08.078</identifier><identifier>PMID: 17981032</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Benzimidazoles - chemical synthesis ; Benzimidazoles - chemistry ; Benzimidazoles - pharmacology ; Biological and medical sciences ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cell Growth Processes - drug effects ; Cell Line, Tumor ; Cell proliferation ; General aspects ; Humans ; MDA-MB-231 ; Medical sciences ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacology. Drug treatments ; Spectroscopy, Fourier Transform Infrared ; Trisubstituted benzimidazole</subject><ispartof>Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.432-435</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-fb4dd47cac9cb8d034d2094dfe5d2f09b79d2141f817844c193ba227a5ce9a393</citedby><cites>FETCH-LOGICAL-c415t-fb4dd47cac9cb8d034d2094dfe5d2f09b79d2141f817844c193ba227a5ce9a393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20037463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17981032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thimmegowda, N.R.</creatorcontrib><creatorcontrib>Nanjunda Swamy, S.</creatorcontrib><creatorcontrib>Ananda Kumar, C.S.</creatorcontrib><creatorcontrib>Sunil Kumar, Y.C.</creatorcontrib><creatorcontrib>Chandrappa, S.</creatorcontrib><creatorcontrib>Yip, George W.</creatorcontrib><creatorcontrib>Rangappa, K.S.</creatorcontrib><title>Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A novel series of trisubstituted benzimidazole and its precursors (
3–
7) were synthesised and characterized by using
1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound
N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (
3) was the potent inhibitor.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - chemistry</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Growth Processes - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>General aspects</subject><subject>Humans</subject><subject>MDA-MB-231</subject><subject>Medical sciences</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Trisubstituted benzimidazole</subject><issn>0960-894X</issn><issn>0968-0896</issn><issn>1464-3405</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAUhS0EokPhD7BA3sCKpH5lHEts2vKq1KoLQGJn3dg3Go_yKHYyUue38GPrdEawg5V15e-ce3UOIa85Kznj67Nt2fSuKwVjumR1yXT9hKy4WqtCKlY9JStm1qyojfp5Ql6ktGWMK6bUc3LCtak5k2JFfn-7H6YNppDeU7eBCG7CGPYwhXGgMHiKO-jmwzi2tMFhH_rgYT92SH1Gd_lvh49omBK9i-jmmMaYKCQahk1owrRMWXzz8by4uSiE5HQz9zDQJiKkiToYHEbqsOuyfuxCi_Fx40vyrIUu4avje0p-fP70_fJrcX375ery_LpwildT0TbKe6UdOOOa2jOpvGBG-RYrL1pmGm284Iq3Nde1Uo4b2YAQGiqHBqSRp-TdwTdv_zVjmmwf0nIODDjOyWrGjZH6_2B2lsJUCygOoItjShFbexdDD_HecmaX8uzWLuXZpTzLapvLy6I3R_e56dH_lRzbysDbIwDJQdfGHFxIf7jsJbVay8x9OHCYQ9sFjDa5gDlkH3I9k_Vj-NcdDwVmux0</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Thimmegowda, N.R.</creator><creator>Nanjunda Swamy, S.</creator><creator>Ananda Kumar, C.S.</creator><creator>Sunil Kumar, Y.C.</creator><creator>Chandrappa, S.</creator><creator>Yip, George W.</creator><creator>Rangappa, K.S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation</title><author>Thimmegowda, N.R. ; Nanjunda Swamy, S. ; Ananda Kumar, C.S. ; Sunil Kumar, Y.C. ; Chandrappa, S. ; Yip, George W. ; Rangappa, K.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-fb4dd47cac9cb8d034d2094dfe5d2f09b79d2141f817844c193ba227a5ce9a393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - chemistry</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Growth Processes - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>General aspects</topic><topic>Humans</topic><topic>MDA-MB-231</topic><topic>Medical sciences</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Trisubstituted benzimidazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thimmegowda, N.R.</creatorcontrib><creatorcontrib>Nanjunda Swamy, S.</creatorcontrib><creatorcontrib>Ananda Kumar, C.S.</creatorcontrib><creatorcontrib>Sunil Kumar, Y.C.</creatorcontrib><creatorcontrib>Chandrappa, S.</creatorcontrib><creatorcontrib>Yip, George W.</creatorcontrib><creatorcontrib>Rangappa, K.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thimmegowda, N.R.</au><au>Nanjunda Swamy, S.</au><au>Ananda Kumar, C.S.</au><au>Sunil Kumar, Y.C.</au><au>Chandrappa, S.</au><au>Yip, George W.</au><au>Rangappa, K.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008</date><risdate>2008</risdate><volume>18</volume><issue>1</issue><spage>432</spage><epage>435</epage><pages>432-435</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>A novel series of trisubstituted benzimidazole and its precursors (
3–
7) were synthesised and characterized by using
1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound
N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (
3) was the potent inhibitor.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17981032</pmid><doi>10.1016/j.bmcl.2007.08.078</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.432-435 |
| issn | 0960-894X 0968-0896 1464-3405 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70199379 |
| source | ScienceDirect Journals |
| subjects | Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Growth Processes - drug effects Cell Line, Tumor Cell proliferation General aspects Humans MDA-MB-231 Medical sciences Nuclear Magnetic Resonance, Biomolecular Pharmacology. Drug treatments Spectroscopy, Fourier Transform Infrared Trisubstituted benzimidazole |
| title | Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation |
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