The effects of iron supplementation on serum copper and zinc levels in pregnant women with high-normal hemoglobin

Abstract Objective To evaluate the effect of iron supplementation on serum copper and zinc levels. Method In a randomized, double-blind, placebo-controlled trial, 66 pregnant women with hemoglobin 13.2 g/dL or greater between the 13th and 18th week of pregnancy were randomized into case and control...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2008-02, Vol.100 (2), p.133-135
Main Authors: Ziaei, Saeideh, Janghorban, R., Shariatdoust, Sosan, Faghihzadeh, Sofhrate
Format: Article
Language:English
Subjects:
Biological and medical sciences
Copper
Copper - blood
Double-Blind Method
Female
Ferrous Compounds - pharmacology
Gynecology. Andrology. Obstetrics
Hematinics - pharmacology
Hemoglobin
Hemoglobins - analysis
Humans
Iron supplementation
Medical sciences
Obstetrics and Gynecology
Pregnancy
Zinc
Zinc - blood
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Summary:Abstract Objective To evaluate the effect of iron supplementation on serum copper and zinc levels. Method In a randomized, double-blind, placebo-controlled trial, 66 pregnant women with hemoglobin 13.2 g/dL or greater between the 13th and 18th week of pregnancy were randomized into case and control groups. From the 20th week until the end of pregnancy the case group received one ferrous sulfate tablet containing 50 mg elemental iron daily, while the control group received placebo. Hemoglobin, ferritin, copper, and zinc levels at 24-28 and 32-36 weeks of pregnancy were measured and compared. Results In the case group, serum copper levels in the second and third trimester were significantly lower than the control group ( P < 0.01 and P < 0.001, respectively). Serum zinc levels in the case group in the second and third trimester were also significantly lower than the control group ( P < 0.001). Conclusion Iron supplementation in pregnant women with hemoglobin greater than 13.2 g/dL reduces serum levels of copper and zinc.
ISSN:0020-7292
1879-3479
DOI:10.1016/j.ijgo.2007.07.026