New Cytotoxic 14-Membered Macrolides from Marine-Derived Fungus Aspergillus ostianus

Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D a...

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Bibliographic Details
Published in:Organic letters 2008-01, Vol.10 (2), p.225-228
Main Authors: Kito, Keijiro, Ookura, Ryuhei, Yoshida, Sanae, Namikoshi, Michio, Ooi, Takashi, Kusumi, Takenori
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Aspergillus - chemistry
Drug Screening Assays, Antitumor
Macrolides - chemistry
Macrolides - isolation & purification
Macrolides - pharmacology
Marine Biology
Methicillin Resistance - drug effects
Mice
Microbial Sensitivity Tests
Molecular Structure
Tumor Cells, Cultured
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Summary:Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol702598q