Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid

Acute lung injury (ALI) is one of most serious complications to occur after an esophagectomy for esophageal cancer. However, the pathogenesis of ALI is still unclear. The cytokine levels of pleural drainage fluid as well as peripheral blood were measured in 27 patients who had undergone an extended...

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Bibliographic Details
Published in:Diseases of the esophagus 2008-02, Vol.21 (1), p.30-36
Main Authors: Morita, M., Yoshida, R., Ikeda, K., Egashira, A., Oki, E., Sadanaga, N., Kakeji, Y., Ichiki, Y., Sugio, K., Yasumoto, K., Maehara, Y.
Format: Article
Language:English
Subjects:
acute lung injury
Aged
Anastomosis, Surgical - adverse effects
ARDS
Carcinoma, Squamous Cell - surgery
Colon - transplantation
cytokine
Cytokines - analysis
esophageal cancer
Esophageal Neoplasms - surgery
esophagectomy
Esophagectomy - methods
Esophagoplasty
Female
Humans
Logistic Models
Male
Middle Aged
Pleural Effusion - chemistry
Postoperative Complications
Respiration, Artificial
Respiratory Distress Syndrome, Adult - etiology
Systemic Inflammatory Response Syndrome - etiology
Time Factors
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Summary:Acute lung injury (ALI) is one of most serious complications to occur after an esophagectomy for esophageal cancer. However, the pathogenesis of ALI is still unclear. The cytokine levels of pleural drainage fluid as well as peripheral blood were measured in 27 patients who had undergone an extended radical esophagectomy. Both the clinical factors and cytokine levels were compared between 11 patients with (group I) and 16 without ALI (group II). ALI occurred more frequently in patients who underwent colon interposition than in those who received a gastric tube reconstruction (86%vs 25%, P = 0.009). The operation time of group I was significantly longer than that of group II. A logistic regression analysis revealed colon interposition to be an independent factor associated with the ALI (P 
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2007.00725.x