Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding t...

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Bibliographic Details
Published in:Annals of hematology 2007, Vol.86 (4), p.303-306
Main Authors: Goede, Jeroen S, Misselwitz, Benjamin, Taverna, Christian, Schanz, Urs, Dispenzieri, Angela, Hummel, Yvonne, Trüeb, Ralph M, Fehr, Jörg
Format: Report
Language:English
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Summary:Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.
ISSN:1432-0584