Diagnostic performance and prognostic impact of FDG-PET in suspected recurrence of surgically treated non-small cell lung cancer

The differentiation of recurrent lung cancer and post-therapeutic changes remains a problem for radiological imaging, but FDG-PET allows biological characterisation of tissues by visualising glucose metabolism. We evaluated the diagnostic performance and prognostic impact of FDG-PET in cases of susp...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2006-01, Vol.33 (1), p.13-21
Main Authors: Hellwig, Dirk, Gröschel, Andreas, Graeter, Thomas P, Hellwig, Anne P, Nestle, Ursula, Schäfers, Hans-Joachim, Sybrecht, Gerhard W, Kirsch, Carl-Martin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - surgery
Female
Fluorodeoxyglucose F18
Germany - epidemiology
Humans
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - mortality
Lung Neoplasms - surgery
Male
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - mortality
Positron-Emission Tomography - methods
Prognosis
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Survival Rate
Treatment Outcome
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Summary:The differentiation of recurrent lung cancer and post-therapeutic changes remains a problem for radiological imaging, but FDG-PET allows biological characterisation of tissues by visualising glucose metabolism. We evaluated the diagnostic performance and prognostic impact of FDG-PET in cases of suspected relapse of lung cancer. In 62 consecutive patients, 73 FDG-PET scans were performed for suspected recurrence after surgical therapy of lung cancer. FDG uptake by lesions was measured as the standardised uptake value (SUV). PET results were compared with the final diagnosis established by biopsy or imaging follow-up. SUV and clinical parameters were analysed as prognostic factors with respect to survival. FDG-PET correctly identified 51 of 55 relapses and gave true negative results in 16 of 18 remissions (sensitivity, specificity, accuracy: 93%, 89%, 92%). SUV in recurrent tumour was higher than in benign post-therapeutic changes (10.6+/-5.1 vs 2.1+/-0.6, p
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-005-1919-4