Metabolomics : A Global Biochemical Approach to Drug Response and Disease

Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics....

Full description

Saved in:
Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2008-01, Vol.48 (1), p.653-683
Main Authors: KADDURAH-DAOUK, Rima, KRISTAL, Bruce S, WEINSHILBOUM, Richard M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomedical Research - methods
Chemistry Techniques, Analytical - methods
General pharmacology
Humans
Medical Informatics - methods
Medical sciences
Metabolism
Miscellaneous
Pharmaceutical Preparations - administration & dosage
Pharmacology. Drug treatments
Phenotype
Systems Biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids-followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.48.113006.094715