Fluorine in medicinal chemistry

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion...

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Bibliographic Details
Published in:Chemical Society reviews 2008-02, Vol.37 (2), p.320-330
Main Authors: Purser, Sophie, Moore, Peter R, Swallow, Steve, Gouverneur, Véronique
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical
Drug Design
Humans
Hydrocarbons, Fluorinated - chemistry
Hydrocarbons, Fluorinated - pharmacology
Molecular Structure
Stereoisomerism
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Summary:It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
ISSN:0306-0012
1460-4744
DOI:10.1039/b610213c