Biclonal post-transplant B-cell lymphoma: report of a case with two distinct cell populations, XX,t(14;18) and XY,t(11;14)

Abstract Lymphoproliferative disorders are more likely to occur in transplant patients compared to the general population. Typically in these patients, lymphomas occur within 6-10 months following transplant and are Epstein-Barr virus (EBV) positive. We report a biclonal apparently EBV negative lymp...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2007-03, Vol.173 (2), p.150-153
Main Authors: Dennis, Katie L, Wallentine, Steven L, Vanveldhuizen, Peter J, Persons, Diane L, Mathur, Sharad C
Format: Article
Language:English
Subjects:
Aged
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Chromosomes, Human, X
Chromosomes, Human, Y
Clone Cells - metabolism
Clone Cells - pathology
Epstein-Barr virus
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Kidney Transplantation
Lymphoma, B-Cell - genetics
Lymphoma, B-Cell - pathology
Male
Medical Education
Sex Chromosome Aberrations
Translocation, Genetic
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Summary:Abstract Lymphoproliferative disorders are more likely to occur in transplant patients compared to the general population. Typically in these patients, lymphomas occur within 6-10 months following transplant and are Epstein-Barr virus (EBV) positive. We report a biclonal apparently EBV negative lymphoma occurring in a patient ten years after renal transplant, with karyotypes XX,t(14;18) and XY,t(11;14). Though the biclonal populations also had different sex chromosome compositions, complete evaluation showed that both clones most likely evolved from the patient's native lymphocytes.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2006.09.020