TSE detected in a Belgian ARR-homozygous sheep via active surveillance

It is commonly accepted that scrapie-resistance and -susceptibility in sheep are genetically controlled. Consequently, the selection of sheep with scrapie-resistant genotypes is currently one of the most important objectives of the sheep breeding associations. However, during the last two years, new...

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Bibliographic Details
Published in:The veterinary journal (1997) 2007-03, Vol.173 (2), p.449-451
Main Authors: De Bosschere, Hendrik, Roels, Stefan, Dechamps, Pierre, Vanopdenbosch, Emmanuel
Format: Article
Language:English
Subjects:
Animals
ARR
Atypical scrapie
Breeding
disease detection
disease resistance
disease surveillance
disease transmission
Female
Genetic Predisposition to Disease
Genotype
homozygosity
Nor98
Population Surveillance
PrPSc proteins
Resistant genotypes
scrapie
Scrapie - genetics
selection criteria
Sheep
Sheep Diseases - genetics
TSE
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Summary:It is commonly accepted that scrapie-resistance and -susceptibility in sheep are genetically controlled. Consequently, the selection of sheep with scrapie-resistant genotypes is currently one of the most important objectives of the sheep breeding associations. However, during the last two years, new data have become available on transmissible spongiform encephalopathy (TSE) cases in TSE-resistant sheep in several European Union member states. The present paper describes the first Belgian natural “atypical” TSE case in a sheep with a scrapie-resistant genotype (ARR/ARR) detected via active surveillance. No other infections or diseases were detected in the source flock. The continued finding of new “atypical” TSE cases in sheep with scrapie-resistant genotypes undermines the purpose and efficacy of the breeding programs.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2005.07.014