Clindamycin Versus Unasyn in the Treatment of Facial Cellulitis of Odontogenic Origin in Children

The study was undertaken to characterize the microbiology of dental abscesses in children and to compare clindamycin and ampicillin/sulbactam in the treatment of facial cellulitis of odontogenic origin. Sixty children with acute facial cellulitis of dental origin underwent surgery (extraction or roo...

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Bibliographic Details
Published in:Clinical pediatrics 2007-03, Vol.46 (2), p.154-159
Main Authors: Rush, Demetris E., Abdel-Haq, Nahed, Zhu, Jian-Fu, Aamar, Basim, Malian, Monica
Format: Article
Language:English
Subjects:
Adolescent
Amoxicillin-Potassium Clavulanate Combination - administration & dosage
Ampicillin - administration & dosage
Anti-Bacterial Agents - administration & dosage
Bacteria
Bacterial Infections - drug therapy
Cellulitis - drug therapy
Cellulitis - etiology
Child
Child, Preschool
Children & youth
Clindamycin - administration & dosage
Dental research
Dental surgery
Drug therapy
Face
Female
Humans
Infections
Male
Medical research
Microbiology
Neisseria
Peptostreptococcus
Prevotella
Single-Blind Method
Skin
Sulbactam - administration & dosage
Tooth Diseases - complications
Tooth Diseases - microbiology
Tooth Diseases - surgery
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Summary:The study was undertaken to characterize the microbiology of dental abscesses in children and to compare clindamycin and ampicillin/sulbactam in the treatment of facial cellulitis of odontogenic origin. Sixty children with acute facial cellulitis of dental origin underwent surgery (extraction or root canal procedure) within 24 hours of presentation. Pus samples were cultured aerobically and anaerobically. Patients were randomized (1:1) to receive intravenous ampicillin/sulbactam or clindamycin for 48 hours followed by oral amoxicillin/clavulanate or clindamycin for 7 days. A total of 211 bacterial isolates were recovered from 54 samples. The most common aerobic and facultative organisms were viridans streptococci, Neisseria, and Eikenella species. Among anaerobes, Prevotella and Peptostreptococcus species were the most frequent. No treatment failure occurred in either group. Dental abscesses in children are polymicrobial aerobic/anaerobic infections. Treatment of complicated dental infections with ampicillin plus a β-lactamase inhibitor or clindamycin in combination with surgical drainage is very effective.
ISSN:0009-9228
1938-2707
DOI:10.1177/0009922806289431