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A Wnt-FoxQ2-Nodal Pathway Links Primary and Secondary Axis Specification in Sea Urchin Embryos

The primary (animal-vegetal) (AV) and secondary (oral-aboral) (OA) axes of sea urchin embryos are established by distinct regulatory pathways. However, because experimental perturbations of AV patterning also invariably disrupt OA patterning and radialize the embryo, these two axes must be mechanist...

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Published in:Developmental cell 2008-01, Vol.14 (1), p.97-107
Main Authors: Yaguchi, Shunsuke, Yaguchi, Junko, Angerer, Robert C., Angerer, Lynne M.
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description The primary (animal-vegetal) (AV) and secondary (oral-aboral) (OA) axes of sea urchin embryos are established by distinct regulatory pathways. However, because experimental perturbations of AV patterning also invariably disrupt OA patterning and radialize the embryo, these two axes must be mechanistically linked. Here we show that FoxQ2, which is progressively restricted to the animal plate during cleavage stages, provides this linkage. When AV patterning is prevented by blocking the nuclear function of β-catenin, the animal plate where FoxQ2 is expressed expands throughout the future ectoderm, and expression of nodal, which initiates OA polarity, is blocked. Surprisingly, nodal transcription and OA differentiation are rescued simply by inhibiting FoxQ2 translation. Therefore, restriction of FoxQ2 to the animal plate is a crucial element of canonical Wnt signaling that coordinates patterning along the AV axis with the initiation of OA specification.
doi_str_mv 10.1016/j.devcel.2007.10.012
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source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Animals
beta Catenin - physiology
Biological and medical sciences
Body Patterning - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
DEVBIO
Ectoderm - growth & development
Ectoderm - physiology
Embryo, Nonmammalian - physiology
Embryonic Development - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Molecular and cellular biology
RNA, Messenger - genetics
Sea Urchins - embryology
Transcription Factors - genetics
Transcription Factors - physiology
Wnt Proteins - genetics
Wnt Proteins - physiology
title A Wnt-FoxQ2-Nodal Pathway Links Primary and Secondary Axis Specification in Sea Urchin Embryos
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