Electron ionisation and electrospray ionisation mass spectrometric study of a series of isomeric methyl-, dimethyl- and trimethylalloxazines

Electron ionisation (EI) mass spectra and electrospray ionisation (ESI) mass spectra at different cone voltages of a series of isomeric methyl‐ and dimethylalloxazines are discussed, and compared with those of lumichrome, and 1‐ and 3‐methyllumichrome. Examination of ESI mass spectra taken at a high...

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Bibliographic Details
Published in:Rapid communications in mass spectrometry 2008-02, Vol.22 (3), p.409-416
Main Authors: Prukała, Dorota, Prukała, Wiesław, Koczorowski, Ryszard, Khmelinskii, Igor V., Sikorska, Ewa, Sikorski, Marek
Format: Article
Language:English
Subjects:
Electrons
Flavins - analysis
Flavins - chemistry
Ions
Isomerism
Methylation
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization - methods
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Summary:Electron ionisation (EI) mass spectra and electrospray ionisation (ESI) mass spectra at different cone voltages of a series of isomeric methyl‐ and dimethylalloxazines are discussed, and compared with those of lumichrome, and 1‐ and 3‐methyllumichrome. Examination of ESI mass spectra taken at a higher cone voltage and the use of isotope‐labelled methanol allow us to discuss the fragmentation pathways of [M+H]+ and [M–H]− ions. The fragmentation pathways of all of the compounds and the characteristic fragment ions formed in EI‐MS are compared with published data. The influence of methyl and dimethyl substituents in the benzene ring on the fragmentation pathways leading to the loss of 43 and 45 Da upon both electron and electrospray ionisation is described. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.3378