Correlation of the myocardial performance index with plasma B-type natriuretic peptide levels in patients with mitral regurgitation

• Published in: The International Journal of Cardiovascular Imaging 2008-02, Vol.24 (2), p.151-157
• Main Authors: Sayar, Nurten, Lütfullah Orhan, A., Çakmak, Nazmiye, Yılmaz, Hale, Atmaca, Hüsnü, Tangürek, Burak, Hasdemir, Hakan, Nurkalem, Zekeriya, Ergelen, Mehmet, Aksu, Hale, Yeşilçimen, Kemal
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Biomarkers - blood; Cardiac Imaging; Cardiology; Chronic Disease; Comorbidity; Diastole; Echocardiography; Exercise Test; Female; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Mitral Valve Insufficiency - blood; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - physiopathology; Myocardial Contraction - physiology; Natriuretic Peptide, Brain - blood; Original Paper; Radiology; Statistics, Nonparametric; Systole
• ISSN: 1569-5794; 1573-0743
• DOI: 10.1007/s10554-007-9237-5

Objective The Myocardial performance index (MPI) is an echocardiographic index of combined systolic and diastolic function, calculated as isovolumetric relaxation time plus isovolumetric contraction time divided by ejection time. The aim of this study was to define the correlation of the MPI with plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters in patients with chronic mitral regurgitation (MR). Methods About 33 patients with at least moderate MR of organic etiology were enrolled to the study. All patients undergone complete 2D and Doppler echocardiography. Plasma BNP levels were studied. Results BNP levels in NYHA classes I–III were 9.3 ± 2.2 pg/ml, 61.3 ± 12.2 pg/ml, and 199.6 ± 55.2 pg/ml, respectively (I vs. II P