Brain natriuretic peptide is a good predictor for outcome in cardiac surgery

Background and aim:  The heart secretes brain natriuretic peptide (BNP) in response to myocardial stretch. The aim of this study was to determine whether adverse effects after cardiac surgery were associated with higher serum BNP levels pre‐operatively. Methods:  One hundred and thirty‐five patients...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2008-02, Vol.52 (2), p.182-187
Main Authors: Elíasdóttir, S. B., Klemenzson, G., Torfason, B., Valsson, F.
Format: Article
Language:English
Subjects:
Adverse outcome
Aged
Aged, 80 and over
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - blood
brain natriuretic peptide
cardiac surgery
Cardiac Surgical Procedures - adverse effects
Echocardiography, Transesophageal
euroSCORE
Female
Humans
Length of Stay
Male
Medical sciences
Middle Aged
Natriuretic Peptide, Brain - blood
Postoperative Complications - blood
Postoperative Complications - etiology
Predictive Value of Tests
Preoperative Care
Renal Insufficiency - etiology
ROC Curve
Stroke Volume
Survival Rate
Treatment Outcome
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Summary:Background and aim:  The heart secretes brain natriuretic peptide (BNP) in response to myocardial stretch. The aim of this study was to determine whether adverse effects after cardiac surgery were associated with higher serum BNP levels pre‐operatively. Methods:  One hundred and thirty‐five patients undergoing various cardiac procedures were included in the study, and N‐terminal pro‐BNP (NT‐pro‐BNP) was measured pre‐operatively. Post‐operative complications were defined as follows: (i) a post‐operative length of stay in the intensive care unit (ICU) exceeding 48 h; (ii) mortality at 28 days; (iii) the need for inotropic agents and/or intra‐aortic balloon pump (IABP); and (iv) renal failure. Serum NT‐pro‐BNP values were compared for patients with and without complications. The serum NT‐pro‐BNP level was also correlated with the euroSCORE and ejection fraction (EF). Results:  Pre‐operative serum NT‐pro‐BNP levels were significantly higher in patients with an ICU length of stay of more than 2 days or death prior to post‐operative day 28 (3118 ng/l vs. 705 ng/l; P 
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2007.01451.x