Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides

Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylgly...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2008, Vol.43 (1), p.210-221
Main Authors: Cateni, Francesca, Bonivento, Paolo, Procida, Giuseppe, Zacchigna, Marina, Favretto, Luciana Gabrielli, Scialino, Giuditta, Banfi, Elena
Format: Article
Language:English
Subjects:
1,2- O-Diacyl-3- O-β- d-galactopyranosyl-glycerols
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial activity
Bacteria - drug effects
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Diglycerides - chemical synthesis
Diglycerides - chemistry
Diglycerides - pharmacology
Fundamental and applied biological sciences. Psychology
Fungi - drug effects
General aspects
Lipases
Mass Spectrometry
Medical sciences
Methods. Procedures. Technologies
Microbial Sensitivity Tests
Monogalactosyl diglycerides
Pharmacology. Drug treatments
Synthesis
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Summary:Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity. [Display omitted] Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2007.03.012