CARD15 variants in patients with sporadic Parkinson's disease

Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of sporadic Parkinson's disease (PD). In the current study, the frequency of CARD15/NOD2 gene variants (R702W, G908R, L1007fs), previously associated with Crohn's disease—a common inflammatory...

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Bibliographic Details
Published in:Neuroscience research 2007-03, Vol.57 (3), p.473-476
Main Authors: Bialecka, Monika, Kurzawski, Mateusz, Klodowska-Duda, Gabriela, Opala, Grzegorz, Juzwiak, Stefania, Kurzawski, Grzegorz, Tan, Eng-King, Drozdzik, Marek
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
CARD15
Crohn Disease - genetics
DNA Mutational Analysis
Encephalitis - genetics
Encephalitis - metabolism
Encephalitis - physiopathology
Female
Gene Frequency - genetics
Genetic Markers - genetics
Genetic polymorphism
Genetic Predisposition to Disease - genetics
Genetic Testing
Genetic Variation - genetics
Genotype
Humans
Male
Middle Aged
Mutation - genetics
NOD2
Nod2 Signaling Adaptor Protein - genetics
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson Disease - physiopathology
Parkinson's disease
Polymorphism, Genetic - genetics
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Summary:Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of sporadic Parkinson's disease (PD). In the current study, the frequency of CARD15/NOD2 gene variants (R702W, G908R, L1007fs), previously associated with Crohn's disease—a common inflammatory bowel disease, have been examined in a group of 308 sporadic PD patients and 220 healthy controls. Significantly higher frequency of total CARD15 variant alleles in PD patients (13.0%) compared to the controls (8.0%, p < 0.02) was observed. 24.0% of PD patients carried at least one CARD15 variant allele compared to 15.5% of healthy controls ( p < 0.02, OR = 1.73). The results of the study suggest, that the polymorphism in CARD15/NOD2 gene may be a risk factor for sporadic PD development, and support the concept of inflammatory pathogenesis of PD.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2006.11.012