Messenger RNA Surveillance Systems Monitoring Proper Translation Termination

Organisms have evolved an elaborate set of quality control systems to ensure the fidelity of the genetic information flow. The mRNA surveillance systems work in this context by monitoring the quality of mRNAs to ensure that they are suitable for translation. In this review, recent achievements in th...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2008-01, Vol.143 (1), p.1-8
Main Author: Akimitsu, Nobuyoshi
Format: Article
Language:English
Subjects:
Animals
Bacteria - genetics
Codon, Nonsense
Mammals - genetics
Models, Genetic
mRNA quality control
mRNA surveillance
Protein Biosynthesis
ribosome
RNA, Bacterial - metabolism
RNA, Messenger - metabolism
stop codon
translation
Yeasts - genetics
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Summary:Organisms have evolved an elaborate set of quality control systems to ensure the fidelity of the genetic information flow. The mRNA surveillance systems work in this context by monitoring the quality of mRNAs to ensure that they are suitable for translation. In this review, recent achievements in the investigation of mRNA surveillance pathways, including nonsense-mediated mRNA decay and nonstop-mediated mRNA surveillance pathway, will be discussed.
ISSN:0021-924X
1756-2651
DOI:10.1093/jb/mvm204