Coronary Involvement in Infants with Kawasaki Disease Treated with Intravenous γ-Globulin

Aim To analyze the clinical spectrum and the incidence of coronary involvement in infants with typical Kawasaki's disease (KD). Patients and Methods A retrospective study was performed on children one year of age or younger diagnosed from February 1992 to January 2006 with typical KD. Children...

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Bibliographic Details
Published in:Pediatric cardiology 2008, Vol.29 (1), p.31-35
Main Authors: Moreno, Noelia, Méndez-Echevarría, Ana, de Inocencio, Jaime, del Castillo, Fernando, Baquero-Artigao, Fernando, García-Miguel, María Jesús, de José, María Isabel, Aracil, Javier
Format: Article
Language:English
Subjects:
Cardiac Surgery
Cardiology
Child
Child, Preschool
Coronary Artery Disease - etiology
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Immunologic Factors - therapeutic use
Male
Medicine
Medicine & Public Health
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - diagnosis
Mucocutaneous Lymph Node Syndrome - drug therapy
Original
Retrospective Studies
Vascular Surgery
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Summary:Aim To analyze the clinical spectrum and the incidence of coronary involvement in infants with typical Kawasaki's disease (KD). Patients and Methods A retrospective study was performed on children one year of age or younger diagnosed from February 1992 to January 2006 with typical KD. Children with incomplete forms of the disease were not included. Results Twenty-five infants were diagnosed with KD during the study period. The median age of the patients was 10 months (range, 4–12 months). All children but one received intravenous gammaglobulin (IVIG), 84% before the 10th day of disease. Seven patients (28%) required the administration of more than one dose of IVIG, because persistence of fever. Coronary artery disease (CAD) was recorded in 6 cases (24%), five of them being boys. All patients with CAD were treated with ASA plus IVIG and 84% of them received this therapy within the first 10 days of the KD onset. Conclusions In spite of the exclusion of our study of incomplete presentations and of an early administration of IVIG in our patients, we have observed a high rate of infants who developed CAD, which is similar to the one reported in children who do not receive IVIG.
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-007-9068-0