The Role of Molecular Imaging in Drug Discovery and Development

Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof‐of‐concept testing early in the drug discovery and development process. By facilitating better an...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2008-02, Vol.83 (2), p.349-353
Main Author: Hargreaves, RJ
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Atherosclerosis - diagnosis
Atherosclerosis - drug therapy
Biological and medical sciences
Biomarkers, Pharmacological - analysis
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Central Nervous System Agents - pharmacology
Central Nervous System Agents - therapeutic use
Diagnostic Imaging - methods
Drug Design
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Medical sciences
Neoplasms - diagnosis
Neoplasms - drug therapy
Optics and Photonics
Patient Selection
Pharmacology. Drug treatments
Positron-Emission Tomography
Technology, Pharmaceutical - methods
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography
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Summary:Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof‐of‐concept testing early in the drug discovery and development process. By facilitating better and faster decision‐making, molecule and mechanism–based failures can be identified and eliminated from a research portfolio early in development thereby focusing research efforts on the best drug candidates and therapeutic hypotheses. Molecular imaging can be used to improve the cost‐effectiveness of studying unprecedented mechanisms, decrease cycle time, and improve drug pipeline quality. Clinical Pharmacology & Therapeutics (2008); doi:10.1038/sj.clpt.6100467
ISSN:0009-9236
1532-6535
DOI:10.1038/sj.clpt.6100467