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The Role of Molecular Imaging in Drug Discovery and Development
Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof‐of‐concept testing early in the drug discovery and development process. By facilitating better an...
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| Published in: | Clinical pharmacology and therapeutics 2008-02, Vol.83 (2), p.349-353 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4617-f7021f7bd0f9a965a881cdd1ee362d1c74bcf20899a65efa772387ab3fec14f73 |
| container_end_page | 353 |
| container_issue | 2 |
| container_start_page | 349 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 83 |
| creator | Hargreaves, RJ |
| description | Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof‐of‐concept testing early in the drug discovery and development process. By facilitating better and faster decision‐making, molecule and mechanism–based failures can be identified and eliminated from a research portfolio early in development thereby focusing research efforts on the best drug candidates and therapeutic hypotheses. Molecular imaging can be used to improve the cost‐effectiveness of studying unprecedented mechanisms, decrease cycle time, and improve drug pipeline quality.
Clinical Pharmacology & Therapeutics (2008); doi:10.1038/sj.clpt.6100467 |
| doi_str_mv | 10.1038/sj.clpt.6100467 |
| format | article |
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Clinical Pharmacology & Therapeutics (2008); doi:10.1038/sj.clpt.6100467</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Atherosclerosis - diagnosis</subject><subject>Atherosclerosis - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Pharmacological - analysis</subject><subject>Cardiovascular Agents - pharmacology</subject><subject>Cardiovascular Agents - therapeutic use</subject><subject>Central Nervous System Agents - pharmacology</subject><subject>Central Nervous System Agents - therapeutic use</subject><subject>Diagnostic Imaging - methods</subject><subject>Drug Design</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Optics and Photonics</subject><subject>Patient Selection</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Positron-Emission Tomography</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hargreaves, RJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hargreaves, RJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Molecular Imaging in Drug Discovery and Development</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2008-02</date><risdate>2008</risdate><volume>83</volume><issue>2</issue><spage>349</spage><epage>353</epage><pages>349-353</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><coden>CLPTAT</coden><abstract>Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof‐of‐concept testing early in the drug discovery and development process. By facilitating better and faster decision‐making, molecule and mechanism–based failures can be identified and eliminated from a research portfolio early in development thereby focusing research efforts on the best drug candidates and therapeutic hypotheses. Molecular imaging can be used to improve the cost‐effectiveness of studying unprecedented mechanisms, decrease cycle time, and improve drug pipeline quality.
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| fulltext | fulltext |
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| ispartof | Clinical pharmacology and therapeutics, 2008-02, Vol.83 (2), p.349-353 |
| issn | 0009-9236 1532-6535 |
| language | eng |
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| source | Wiley |
| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Atherosclerosis - diagnosis Atherosclerosis - drug therapy Biological and medical sciences Biomarkers, Pharmacological - analysis Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Central Nervous System Agents - pharmacology Central Nervous System Agents - therapeutic use Diagnostic Imaging - methods Drug Design Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Medical sciences Neoplasms - diagnosis Neoplasms - drug therapy Optics and Photonics Patient Selection Pharmacology. Drug treatments Positron-Emission Tomography Technology, Pharmaceutical - methods Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Treatment Outcome Ultrasonography |
| title | The Role of Molecular Imaging in Drug Discovery and Development |
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