Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression

The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexi...

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Bibliographic Details
Published in:FEBS letters 2007-03, Vol.581 (5), p.865-871
Main Authors: Kim, Seo-young, Kim, Joo Young, Kim, Seol-Hee, Bae, Hyun Jin, Yi, Hwaseon, Yoon, Sang Hong, Koo, Bon Sung, Kwon, Moosik, Cho, Jae Youl, Lee, Choong-Eun, Hong, Sungyoul
Format: Article
Language:English
Subjects:
Akt
Anti-cancer effect
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Bacillus subtilis
Bacillus subtilis - chemistry
C-Jun N-terminal kinase
Caspase 3 - metabolism
CDKs
Cell Cycle - drug effects
Cell cycle arrest
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Collagen Type XI - metabolism
cyclin-dependent kinases
ERK
extracellular-related protein kinase
Fas Ligand Protein - metabolism
fas Receptor - metabolism
Humans
IKK
IκB kinase
JNK
Lipopeptides
MAPK
mitogen-activated protein kinase
PARP
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Phosphoinositide 3-kinase
PI3K
poly (ADP-ribose) polymerase
Signal Transduction - drug effects
Surfactin
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Summary:The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21 WAF1/Cip1, p53, CDK2 and cyclin E. The anti-proliferative activity of surfactin was mediated by inhibiting extracellular-related protein kinase and phosphoinositide 3-kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2007.01.059