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Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression

The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexi...

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Published in:	FEBS letters 2007-03, Vol.581 (5), p.865-871
Main Authors:	Kim, Seo-young, Kim, Joo Young, Kim, Seol-Hee, Bae, Hyun Jin, Yi, Hwaseon, Yoon, Sang Hong, Koo, Bon Sung, Kwon, Moosik, Cho, Jae Youl, Lee, Choong-Eun, Hong, Sungyoul
Format:	Article
Language:	English
Subjects:	Akt Anti-cancer effect Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bacillus subtilis Bacillus subtilis - chemistry C-Jun N-terminal kinase Caspase 3 - metabolism CDKs Cell Cycle - drug effects Cell cycle arrest Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Collagen Type XI - metabolism cyclin-dependent kinases ERK extracellular-related protein kinase Fas Ligand Protein - metabolism fas Receptor - metabolism Humans IKK IκB kinase JNK Lipopeptides MAPK mitogen-activated protein kinase PARP Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Phosphoinositide 3-kinase PI3K poly (ADP-ribose) polymerase Signal Transduction - drug effects Surfactin
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creator	Kim, Seo-young Kim, Joo Young Kim, Seol-Hee Bae, Hyun Jin Yi, Hwaseon Yoon, Sang Hong Koo, Bon Sung Kwon, Moosik Cho, Jae Youl Lee, Choong-Eun Hong, Sungyoul
description	The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21 WAF1/Cip1, p53, CDK2 and cyclin E. The anti-proliferative activity of surfactin was mediated by inhibiting extracellular-related protein kinase and phosphoinositide 3-kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.
doi_str_mv	10.1016/j.febslet.2007.01.059
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Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21 WAF1/Cip1, p53, CDK2 and cyclin E. The anti-proliferative activity of surfactin was mediated by inhibiting extracellular-related protein kinase and phosphoinositide 3-kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2007.01.059</identifier><identifier>PMID: 17292358</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Akt ; Anti-cancer effect ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Bacillus subtilis ; Bacillus subtilis - chemistry ; C-Jun N-terminal kinase ; Caspase 3 - metabolism ; CDKs ; Cell Cycle - drug effects ; Cell cycle arrest ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Collagen Type XI - metabolism ; cyclin-dependent kinases ; ERK ; extracellular-related protein kinase ; Fas Ligand Protein - metabolism ; fas Receptor - metabolism ; Humans ; IKK ; IκB kinase ; JNK ; Lipopeptides ; MAPK ; mitogen-activated protein kinase ; PARP ; Peptides, Cyclic - isolation & purification ; Peptides, Cyclic - pharmacology ; Phosphoinositide 3-kinase ; PI3K ; poly (ADP-ribose) polymerase ; Signal Transduction - drug effects ; Surfactin</subject><ispartof>FEBS letters, 2007-03, Vol.581 (5), p.865-871</ispartof><rights>2007 Federation of European Biochemical Societies</rights><rights>FEBS Letters 581 (2007) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5060-d1ac83981a8cf6c8d42ef2f23540d2fc13f14736799ed73d5d0b8cc5da7e275f3</citedby><cites>FETCH-LOGICAL-c5060-d1ac83981a8cf6c8d42ef2f23540d2fc13f14736799ed73d5d0b8cc5da7e275f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579307001020$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17292358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seo-young</creatorcontrib><creatorcontrib>Kim, Joo Young</creatorcontrib><creatorcontrib>Kim, Seol-Hee</creatorcontrib><creatorcontrib>Bae, Hyun Jin</creatorcontrib><creatorcontrib>Yi, Hwaseon</creatorcontrib><creatorcontrib>Yoon, Sang Hong</creatorcontrib><creatorcontrib>Koo, Bon Sung</creatorcontrib><creatorcontrib>Kwon, Moosik</creatorcontrib><creatorcontrib>Cho, Jae Youl</creatorcontrib><creatorcontrib>Lee, Choong-Eun</creatorcontrib><creatorcontrib>Hong, Sungyoul</creatorcontrib><title>Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. 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Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.</description><subject>Akt</subject><subject>Anti-cancer effect</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bacillus subtilis</subject><subject>Bacillus subtilis - chemistry</subject><subject>C-Jun N-terminal kinase</subject><subject>Caspase 3 - metabolism</subject><subject>CDKs</subject><subject>Cell Cycle - drug effects</subject><subject>Cell cycle arrest</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Collagen Type XI - metabolism</subject><subject>cyclin-dependent kinases</subject><subject>ERK</subject><subject>extracellular-related protein kinase</subject><subject>Fas Ligand Protein - metabolism</subject><subject>fas Receptor - metabolism</subject><subject>Humans</subject><subject>IKK</subject><subject>IκB kinase</subject><subject>JNK</subject><subject>Lipopeptides</subject><subject>MAPK</subject><subject>mitogen-activated protein kinase</subject><subject>PARP</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Phosphoinositide 3-kinase</subject><subject>PI3K</subject><subject>poly (ADP-ribose) polymerase</subject><subject>Signal Transduction - drug effects</subject><subject>Surfactin</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNUk1v1DAUtBCILoWfAPKJE1me7SR2TohWLUWqxKFwtrz2c-WVNwl2kmp_Bv8YR7sSx3Ly18y8eZ5HyHsGWwas_bzfetzliNOWA8gtsC003QuyYUqKStStekk2AKyuGtmJC_Im5z2Us2Lda3LBJO-4aNSG_HmYkzd2Cj31aTjQK2NDjHOmed5NIYZMXchjNMdMTT-FakxDDB6TmcKCFL1HO9ElGGrGYZyGXAihd3MRHPpP1GKM1B5tRGpSwjwVEVek0xIWE2kOj72JoX8sV-NY3nNhvSWvvIkZ353XS_Lr9ubn9V11_-Pb9-uv95VtoIXKMWOV6BQzyvrWKldz9NyXrmpw3FsmPKulaGXXoZPCNQ52ytrGGYlcNl5cko8n3dLS77l404eQV8Omx2HOWgJnXavgWSCHlolGrsDmBLRpyDmh12MKB5OOmoFeQ9N7fQ5Nr6FpYLqEVngfzgXm3QHdP9Y5pQK4OwGeQsTj_6nq25sr_rBOwDoAIMsO-Orxy0kKy9cuAZPONmBv0YVUotRuCM-4_QtoisTp</recordid><startdate>20070306</startdate><enddate>20070306</enddate><creator>Kim, Seo-young</creator><creator>Kim, Joo Young</creator><creator>Kim, Seol-Hee</creator><creator>Bae, Hyun Jin</creator><creator>Yi, Hwaseon</creator><creator>Yoon, Sang Hong</creator><creator>Koo, Bon Sung</creator><creator>Kwon, Moosik</creator><creator>Cho, Jae Youl</creator><creator>Lee, Choong-Eun</creator><creator>Hong, Sungyoul</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070306</creationdate><title>Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression</title><author>Kim, Seo-young ; Kim, Joo Young ; Kim, Seol-Hee ; Bae, Hyun Jin ; Yi, Hwaseon ; Yoon, Sang Hong ; Koo, Bon Sung ; Kwon, Moosik ; Cho, Jae Youl ; Lee, Choong-Eun ; Hong, Sungyoul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5060-d1ac83981a8cf6c8d42ef2f23540d2fc13f14736799ed73d5d0b8cc5da7e275f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Akt</topic><topic>Anti-cancer effect</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bacillus subtilis</topic><topic>Bacillus subtilis - chemistry</topic><topic>C-Jun N-terminal kinase</topic><topic>Caspase 3 - metabolism</topic><topic>CDKs</topic><topic>Cell Cycle - drug effects</topic><topic>Cell cycle arrest</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Collagen Type XI - metabolism</topic><topic>cyclin-dependent kinases</topic><topic>ERK</topic><topic>extracellular-related protein kinase</topic><topic>Fas Ligand Protein - metabolism</topic><topic>fas Receptor - metabolism</topic><topic>Humans</topic><topic>IKK</topic><topic>IκB kinase</topic><topic>JNK</topic><topic>Lipopeptides</topic><topic>MAPK</topic><topic>mitogen-activated protein kinase</topic><topic>PARP</topic><topic>Peptides, Cyclic - isolation & purification</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Phosphoinositide 3-kinase</topic><topic>PI3K</topic><topic>poly (ADP-ribose) polymerase</topic><topic>Signal Transduction - drug effects</topic><topic>Surfactin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seo-young</creatorcontrib><creatorcontrib>Kim, Joo Young</creatorcontrib><creatorcontrib>Kim, Seol-Hee</creatorcontrib><creatorcontrib>Bae, Hyun Jin</creatorcontrib><creatorcontrib>Yi, Hwaseon</creatorcontrib><creatorcontrib>Yoon, Sang Hong</creatorcontrib><creatorcontrib>Koo, Bon Sung</creatorcontrib><creatorcontrib>Kwon, Moosik</creatorcontrib><creatorcontrib>Cho, Jae Youl</creatorcontrib><creatorcontrib>Lee, Choong-Eun</creatorcontrib><creatorcontrib>Hong, Sungyoul</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seo-young</au><au>Kim, Joo Young</au><au>Kim, Seol-Hee</au><au>Bae, Hyun Jin</au><au>Yi, Hwaseon</au><au>Yoon, Sang Hong</au><au>Koo, Bon Sung</au><au>Kwon, Moosik</au><au>Cho, Jae Youl</au><au>Lee, Choong-Eun</au><au>Hong, Sungyoul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2007-03-06</date><risdate>2007</risdate><volume>581</volume><issue>5</issue><spage>865</spage><epage>871</epage><pages>865-871</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21 WAF1/Cip1, p53, CDK2 and cyclin E. The anti-proliferative activity of surfactin was mediated by inhibiting extracellular-related protein kinase and phosphoinositide 3-kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>17292358</pmid><doi>10.1016/j.febslet.2007.01.059</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects	Akt Anti-cancer effect Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bacillus subtilis Bacillus subtilis - chemistry C-Jun N-terminal kinase Caspase 3 - metabolism CDKs Cell Cycle - drug effects Cell cycle arrest Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Collagen Type XI - metabolism cyclin-dependent kinases ERK extracellular-related protein kinase Fas Ligand Protein - metabolism fas Receptor - metabolism Humans IKK IκB kinase JNK Lipopeptides MAPK mitogen-activated protein kinase PARP Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Phosphoinositide 3-kinase PI3K poly (ADP-ribose) polymerase Signal Transduction - drug effects Surfactin
title	Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression
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