Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei—infected mouse macrophages requires bacterial internalization

We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators wa...

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Bibliographic Details
Published in:Microbial pathogenesis 2007-02, Vol.42 (2), p.104-110
Main Authors: Ekchariyawat, P., Pudla, S., Limposuwan, K., Arjcharoen, S., Sirisinha, S., Utaisincharoen, P.
Format: Article
Language:English
Subjects:
Animals
B. pseudomallei
Bacteria
Bacterial diseases
Bacteriology
Biological and medical sciences
Burkholderia pseudomallei
Burkholderia pseudomallei - physiology
Cell Line
CIS
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Infectious diseases
Macrophages - metabolism
Macrophages - microbiology
Medical sciences
Melioidosis
Melioidosis - metabolism
Melioidosis - microbiology
Mice
Microbiology
Miscellaneous
Signal Transduction
SOCS
SOCS3
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins - metabolism
Tropical bacterial diseases
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Summary:We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2006.11.004