A Solid-Phase Route to 18F-Labeled Tracers, Exemplified by the Synthesis of [18F]2-Fluoro-2-deoxy-D-glucose

Scintillating synthesis: 18F‐Containing radiopharmaceuticals can be prepared by using [18F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [18F]fluoro‐2‐d...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (6), p.941-944
Main Authors: Brown, Lynda J., Bouvet, Denis R., Champion, Sue, Gibson, Alex M., Hu, Yulai, Jackson, Alex, Khan, Imtiaz, Ma, Nianchun, Millot, Nicholas, Wadsworth, Harry, Brown, Richard C. D.
Format: Article
Language:English
Subjects:
fluorine
Fluorine Radioisotopes - chemistry
Fluorodeoxyglucose F18 - chemical synthesis
Fluorodeoxyglucose F18 - chemistry
Molecular Conformation
positron emission tomography
radiopharmaceuticals
solid-phase synthesis
Stereoisomerism
synthetic methods
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Summary:Scintillating synthesis: 18F‐Containing radiopharmaceuticals can be prepared by using [18F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [18F]fluoro‐2‐deoxy‐D‐glucose in good radiochemical yield and with high chemical purity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603394