Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

A series of simple synthetic flavonoid derivatives were found to have significant antifungal activity. Two of the compounds also displayed antibacterial activity against methicillin-resistant Staphylococcus aureus. Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rea...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-01, Vol.18 (2), p.518-522
Main Authors: Abdel Ghani, Sherif B., Weaver, Louise, Zidan, Zidan H., Ali, Hussein M., Keevil, C. William, Brown, Richard C.D.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibacterial
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal
Antifungal agents
Aspergillus niger
Aspergillus niger - drug effects
Biological and medical sciences
Flavonoids
Flavonoids - chemical synthesis
Flavonoids - pharmacology
Fusarium
Fusarium - drug effects
General aspects
Medical sciences
Methicillin Resistance
Microbial Sensitivity Tests
Microwaves
Pharmacology. Drug treatments
Staphylococcus aureus
Staphylococcus aureus - drug effects
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Summary:A series of simple synthetic flavonoid derivatives were found to have significant antifungal activity. Two of the compounds also displayed antibacterial activity against methicillin-resistant Staphylococcus aureus. Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2007.11.081