Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease

The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP level...

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Bibliographic Details
Published in:Pediatric cardiology 2008, Vol.29 (1), p.70-75
Main Authors: Berry, J. G., Askovich, B., Shaddy, R. E., Hawkins, J. A., Cowley, C. G.
Format: Article
Language:English
Subjects:
Cardiac Surgery
Cardiology
Cardiotonic Agents - administration & dosage
Dobutamine - administration & dosage
Female
Fontan Procedure
Heart Bypass, Right
Heart Defects, Congenital - blood
Heart Defects, Congenital - surgery
Heart Ventricles - abnormalities
Humans
Infant
Length of Stay
Male
Medicine
Medicine & Public Health
Milrinone - administration & dosage
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Palliative Care
Postoperative Period
Prognosis
Prospective Studies
Vascular Surgery
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Summary:The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP levels were measured at baseline, after cardiopulmonary bypass, 6 to 12 hours after surgery, and then daily until indwelling vascular catheters were removed. Outcome measures included length of mechanical ventilation, inotropic support, and hospital stay. Twenty subjects underwent 23 surgical procedures (13 Norwood, 5 BCPA, and 5 Fontan). BNP levels were significantly higher in patients undergoing a Norwood procedure compared with a BCPA or Fontan procedure ( p  
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-007-9012-3