Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease

The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP level...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric cardiology 2008, Vol.29 (1), p.70-75
Main Authors: Berry, J. G., Askovich, B., Shaddy, R. E., Hawkins, J. A., Cowley, C. G.
Format: Article
Language:English
Subjects:
Cardiac Surgery
Cardiology
Cardiotonic Agents - administration & dosage
Dobutamine - administration & dosage
Female
Fontan Procedure
Heart Bypass, Right
Heart Defects, Congenital - blood
Heart Defects, Congenital - surgery
Heart Ventricles - abnormalities
Humans
Infant
Length of Stay
Male
Medicine
Medicine & Public Health
Milrinone - administration & dosage
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Palliative Care
Postoperative Period
Prognosis
Prospective Studies
Vascular Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3
cites cdi_FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3
container_end_page 75
container_issue 1
container_start_page 70
container_title Pediatric cardiology
container_volume 29
creator Berry, J. G.
Askovich, B.
Shaddy, R. E.
Hawkins, J. A.
Cowley, C. G.
description The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP levels were measured at baseline, after cardiopulmonary bypass, 6 to 12 hours after surgery, and then daily until indwelling vascular catheters were removed. Outcome measures included length of mechanical ventilation, inotropic support, and hospital stay. Twenty subjects underwent 23 surgical procedures (13 Norwood, 5 BCPA, and 5 Fontan). BNP levels were significantly higher in patients undergoing a Norwood procedure compared with a BCPA or Fontan procedure ( p  
doi_str_mv 10.1007/s00246-007-9012-3
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70223809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70223809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3</originalsourceid><addsrcrecordid>eNp9kE1PGzEQhq0KVALtD-il8ombwR-b9frYhrYgIRqJiKvl9c4GI8dOba8qbv3p9SqRuHGa0bwf0jwIfWH0ilEqrzOlvGlJXYmijBPxAS1YIzhhSrITtKBMckLbRpyh85xfKKUd7ZYf0RmTrWyF5Av0b53iNsRcnMVPxk-A44i_k83rHvCDKclNCWZtDfviBsAu4McpbZ01Hq-N984UF8McWj07PyQI-K8rz_jRha0H8gShdlgPeBXDFoIrNXcLJhV84zKYDJ_Q6Wh8hs_HeYE2P39sVrfk_vevu9W3e2JFwwtZ9tIYIxrGh7broeXMMsGlapa9WA4WVM8Ztd0o611aMKoRbavGUQ5qNGoUF-jyULtP8c8Eueidyxa8NwHilLWknIuOqmpkB6NNMecEo94ntzPpVTOqZ-r6QF3P60xdi5r5eiyf-h0Mb4kj5mrgB0OuUuWQ9EucUqj_vtP6HzGWjpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70223809</pqid></control><display><type>article</type><title>Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease</title><source>Springer Link</source><creator>Berry, J. G. ; Askovich, B. ; Shaddy, R. E. ; Hawkins, J. A. ; Cowley, C. G.</creator><creatorcontrib>Berry, J. G. ; Askovich, B. ; Shaddy, R. E. ; Hawkins, J. A. ; Cowley, C. G.</creatorcontrib><description>The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP levels were measured at baseline, after cardiopulmonary bypass, 6 to 12 hours after surgery, and then daily until indwelling vascular catheters were removed. Outcome measures included length of mechanical ventilation, inotropic support, and hospital stay. Twenty subjects underwent 23 surgical procedures (13 Norwood, 5 BCPA, and 5 Fontan). BNP levels were significantly higher in patients undergoing a Norwood procedure compared with a BCPA or Fontan procedure ( p  &lt; 0.01). BNP levels measured 6 to 12 hours after surgery were predictive of duration of hospitalization ( p  = 0.005) and inotropic support ( p  = 0.01). An increase in BNP level within 48 hours of extubation was observed in 92% of patients undergoing a Norwood procedure. Early postoperative BNP levels correlate significantly with the ensuing duration of inotropic support and length of hospitalization. An increase in BNP after extubation may be reflective of the degree of underlying cardiopulmonary instability. Further investigation is necessary to define this important relation.</description><identifier>ISSN: 0172-0643</identifier><identifier>EISSN: 1432-1971</identifier><identifier>DOI: 10.1007/s00246-007-9012-3</identifier><identifier>PMID: 17676372</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Cardiac Surgery ; Cardiology ; Cardiotonic Agents - administration &amp; dosage ; Dobutamine - administration &amp; dosage ; Female ; Fontan Procedure ; Heart Bypass, Right ; Heart Defects, Congenital - blood ; Heart Defects, Congenital - surgery ; Heart Ventricles - abnormalities ; Humans ; Infant ; Length of Stay ; Male ; Medicine ; Medicine &amp; Public Health ; Milrinone - administration &amp; dosage ; Multivariate Analysis ; Natriuretic Peptide, Brain - blood ; Palliative Care ; Postoperative Period ; Prognosis ; Prospective Studies ; Vascular Surgery</subject><ispartof>Pediatric cardiology, 2008, Vol.29 (1), p.70-75</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3</citedby><cites>FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17676372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berry, J. G.</creatorcontrib><creatorcontrib>Askovich, B.</creatorcontrib><creatorcontrib>Shaddy, R. E.</creatorcontrib><creatorcontrib>Hawkins, J. A.</creatorcontrib><creatorcontrib>Cowley, C. G.</creatorcontrib><title>Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease</title><title>Pediatric cardiology</title><addtitle>Pediatr Cardiol</addtitle><addtitle>Pediatr Cardiol</addtitle><description>The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP levels were measured at baseline, after cardiopulmonary bypass, 6 to 12 hours after surgery, and then daily until indwelling vascular catheters were removed. Outcome measures included length of mechanical ventilation, inotropic support, and hospital stay. Twenty subjects underwent 23 surgical procedures (13 Norwood, 5 BCPA, and 5 Fontan). BNP levels were significantly higher in patients undergoing a Norwood procedure compared with a BCPA or Fontan procedure ( p  &lt; 0.01). BNP levels measured 6 to 12 hours after surgery were predictive of duration of hospitalization ( p  = 0.005) and inotropic support ( p  = 0.01). An increase in BNP level within 48 hours of extubation was observed in 92% of patients undergoing a Norwood procedure. Early postoperative BNP levels correlate significantly with the ensuing duration of inotropic support and length of hospitalization. An increase in BNP after extubation may be reflective of the degree of underlying cardiopulmonary instability. Further investigation is necessary to define this important relation.</description><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiotonic Agents - administration &amp; dosage</subject><subject>Dobutamine - administration &amp; dosage</subject><subject>Female</subject><subject>Fontan Procedure</subject><subject>Heart Bypass, Right</subject><subject>Heart Defects, Congenital - blood</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Heart Ventricles - abnormalities</subject><subject>Humans</subject><subject>Infant</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Milrinone - administration &amp; dosage</subject><subject>Multivariate Analysis</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Palliative Care</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Vascular Surgery</subject><issn>0172-0643</issn><issn>1432-1971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PGzEQhq0KVALtD-il8ombwR-b9frYhrYgIRqJiKvl9c4GI8dOba8qbv3p9SqRuHGa0bwf0jwIfWH0ilEqrzOlvGlJXYmijBPxAS1YIzhhSrITtKBMckLbRpyh85xfKKUd7ZYf0RmTrWyF5Av0b53iNsRcnMVPxk-A44i_k83rHvCDKclNCWZtDfviBsAu4McpbZ01Hq-N984UF8McWj07PyQI-K8rz_jRha0H8gShdlgPeBXDFoIrNXcLJhV84zKYDJ_Q6Wh8hs_HeYE2P39sVrfk_vevu9W3e2JFwwtZ9tIYIxrGh7broeXMMsGlapa9WA4WVM8Ztd0o611aMKoRbavGUQ5qNGoUF-jyULtP8c8Eueidyxa8NwHilLWknIuOqmpkB6NNMecEo94ntzPpVTOqZ-r6QF3P60xdi5r5eiyf-h0Mb4kj5mrgB0OuUuWQ9EucUqj_vtP6HzGWjpg</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Berry, J. G.</creator><creator>Askovich, B.</creator><creator>Shaddy, R. E.</creator><creator>Hawkins, J. A.</creator><creator>Cowley, C. G.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease</title><author>Berry, J. G. ; Askovich, B. ; Shaddy, R. E. ; Hawkins, J. A. ; Cowley, C. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiotonic Agents - administration &amp; dosage</topic><topic>Dobutamine - administration &amp; dosage</topic><topic>Female</topic><topic>Fontan Procedure</topic><topic>Heart Bypass, Right</topic><topic>Heart Defects, Congenital - blood</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Heart Ventricles - abnormalities</topic><topic>Humans</topic><topic>Infant</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Milrinone - administration &amp; dosage</topic><topic>Multivariate Analysis</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Palliative Care</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berry, J. G.</creatorcontrib><creatorcontrib>Askovich, B.</creatorcontrib><creatorcontrib>Shaddy, R. E.</creatorcontrib><creatorcontrib>Hawkins, J. A.</creatorcontrib><creatorcontrib>Cowley, C. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berry, J. G.</au><au>Askovich, B.</au><au>Shaddy, R. E.</au><au>Hawkins, J. A.</au><au>Cowley, C. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease</atitle><jtitle>Pediatric cardiology</jtitle><stitle>Pediatr Cardiol</stitle><addtitle>Pediatr Cardiol</addtitle><date>2008</date><risdate>2008</risdate><volume>29</volume><issue>1</issue><spage>70</spage><epage>75</epage><pages>70-75</pages><issn>0172-0643</issn><eissn>1432-1971</eissn><abstract>The objective of this prospective study was to assess the prognostic role of perioperative B-type natriuretic peptide (BNP) levels in infants and children with single-ventricle congenital heart disease undergoing Norwood, bidirectional cavopulmonary anastomosis (BCPA), or Fontan operation. BNP levels were measured at baseline, after cardiopulmonary bypass, 6 to 12 hours after surgery, and then daily until indwelling vascular catheters were removed. Outcome measures included length of mechanical ventilation, inotropic support, and hospital stay. Twenty subjects underwent 23 surgical procedures (13 Norwood, 5 BCPA, and 5 Fontan). BNP levels were significantly higher in patients undergoing a Norwood procedure compared with a BCPA or Fontan procedure ( p  &lt; 0.01). BNP levels measured 6 to 12 hours after surgery were predictive of duration of hospitalization ( p  = 0.005) and inotropic support ( p  = 0.01). An increase in BNP level within 48 hours of extubation was observed in 92% of patients undergoing a Norwood procedure. Early postoperative BNP levels correlate significantly with the ensuing duration of inotropic support and length of hospitalization. An increase in BNP after extubation may be reflective of the degree of underlying cardiopulmonary instability. Further investigation is necessary to define this important relation.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>17676372</pmid><doi>10.1007/s00246-007-9012-3</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0172-0643
ispartof Pediatric cardiology, 2008, Vol.29 (1), p.70-75
issn 0172-0643
1432-1971
language eng
recordid cdi_proquest_miscellaneous_70223809
source Springer Link
subjects Cardiac Surgery
Cardiology
Cardiotonic Agents - administration & dosage
Dobutamine - administration & dosage
Female
Fontan Procedure
Heart Bypass, Right
Heart Defects, Congenital - blood
Heart Defects, Congenital - surgery
Heart Ventricles - abnormalities
Humans
Infant
Length of Stay
Male
Medicine
Medicine & Public Health
Milrinone - administration & dosage
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Palliative Care
Postoperative Period
Prognosis
Prospective Studies
Vascular Surgery
title Prognostic Value of B-Type Natriuretic Peptide in Surgical Palliation of Children with Single-Ventricle Congenital Heart Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T02%3A16%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Value%20of%20B-Type%20Natriuretic%20Peptide%20in%20Surgical%20Palliation%20of%20Children%20with%20Single-Ventricle%20Congenital%20Heart%20Disease&rft.jtitle=Pediatric%20cardiology&rft.au=Berry,%20J.%20G.&rft.date=2008&rft.volume=29&rft.issue=1&rft.spage=70&rft.epage=75&rft.pages=70-75&rft.issn=0172-0643&rft.eissn=1432-1971&rft_id=info:doi/10.1007/s00246-007-9012-3&rft_dat=%3Cproquest_cross%3E70223809%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c342t-5b7aaa3412d68be621c1327945b35dce9b210c8f71c17cea943669ff7d9fa9f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70223809&rft_id=info:pmid/17676372&rfr_iscdi=true