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Juvenile idiopathic arthritis

Summary Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptom...

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Published in:The Lancet (British edition) 2007-03, Vol.369 (9563), p.767-778
Main Authors: Ravelli, Angelo, Dr, Martini, Alberto, Prof
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description Summary Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of new drugs that are able to inhibit selectively single molecules or pathways.
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This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. 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This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. 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This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. 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subjects Adolescent
Adults
Age
Anemia
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antirheumatic agents
Arthritis
Arthritis, Juvenile - classification
Arthritis, Juvenile - diagnosis
Arthritis, Juvenile - genetics
Arthritis, Juvenile - immunology
Arthritis, Juvenile - therapy
Biological and medical sciences
Bone density
Child
Child development
Child, Preschool
Children & youth
Chronic Disease
Chronic illnesses
Classification
Diagnosis, Differential
Disease control
Disease Progression
Diseases of the osteoarticular system
Drug development
Drugs
Environmental factors
Female
Fever
General aspects
Heterogeneity
HLA Antigens - genetics
Humans
Immune response
Immune system
Immunosuppressive agents
Infant
Inflammation
Inflammation - immunology
Inflammatory joint diseases
Injections, Intra-Articular
Internal Medicine
Joint surgery
Laboratories
Male
Medical sciences
Molecular chains
Pathogenesis
Patients
Physical Therapy Modalities
Prognosis
Psoriasis
Rheumatic diseases
Rheumatoid arthritis
Rheumatology
Risk factors
Steroids - administration & dosage
Treatment Outcome
title Juvenile idiopathic arthritis
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