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Juvenile idiopathic arthritis
Summary Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptom...
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Published in: | The Lancet (British edition) 2007-03, Vol.369 (9563), p.767-778 |
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description | Summary Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of new drugs that are able to inhibit selectively single molecules or pathways. |
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This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. 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This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of new drugs that are able to inhibit selectively single molecules or pathways.</description><subject>Adolescent</subject><subject>Adults</subject><subject>Age</subject><subject>Anemia</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antirheumatic agents</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - classification</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - genetics</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Arthritis, Juvenile - therapy</subject><subject>Biological and medical sciences</subject><subject>Bone density</subject><subject>Child</subject><subject>Child development</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Classification</subject><subject>Diagnosis, Differential</subject><subject>Disease control</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Fever</subject><subject>General aspects</subject><subject>Heterogeneity</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunosuppressive agents</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammatory joint diseases</subject><subject>Injections, Intra-Articular</subject><subject>Internal Medicine</subject><subject>Joint surgery</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular chains</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Physical Therapy Modalities</subject><subject>Prognosis</subject><subject>Psoriasis</subject><subject>Rheumatic diseases</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Steroids - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkE1rFEEQQBtRzCb6EyJBicTDaPVn9VwSJBg_CHhQwVvT211DOs7OrN0zgfx7Z3YXFwLiqS-vX1U9xo45vOXAzbtvwBVUBqU5A3xjQBpZ2UdswRWqSiv8-Zgt_iIH7LCUWwBQBvRTdsBRSmO0WrDjL-MddamlkxRTv_bDTQonPg83OQ2pPGNPGt8Wer57j9iPqw_fLz9V118_fr58f10FbflQKV9Hsr5uJFcceVzqSEsPSNpYi7j0FCnaYAIK6UXgBrAhhZYbwaP3KI_Y6613nfvfI5XBrVIJ1La-o34sDkEIy2s7ga8egLf9mLtpNyfAIGoQG-rlvyhe11xIKeoJ0lso5L6UTI1b57Ty-d5xcHNit0ns5n4O0G0Su1n-YicflyuK-1-7phNwugN8Cb5tsu9CKnvOammtmI--2HI0lb1LlF0JibpAMWUKg4t9-u8q5w8MoU1dmob-onsq-6NdEQ62ktkBuDFY-Qf7cqoR</recordid><startdate>20070303</startdate><enddate>20070303</enddate><creator>Ravelli, Angelo, Dr</creator><creator>Martini, Alberto, Prof</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20070303</creationdate><title>Juvenile idiopathic arthritis</title><author>Ravelli, Angelo, Dr ; Martini, Alberto, Prof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-4a9de8a9f314171db5deba07e568877baeded8c6c723a2c1607fe4781621daa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adults</topic><topic>Age</topic><topic>Anemia</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antirheumatic agents</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - classification</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - genetics</topic><topic>Arthritis, Juvenile - immunology</topic><topic>Arthritis, Juvenile - therapy</topic><topic>Biological and medical sciences</topic><topic>Bone density</topic><topic>Child</topic><topic>Child development</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Chronic Disease</topic><topic>Chronic illnesses</topic><topic>Classification</topic><topic>Diagnosis, Differential</topic><topic>Disease control</topic><topic>Disease Progression</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug development</topic><topic>Drugs</topic><topic>Environmental factors</topic><topic>Female</topic><topic>Fever</topic><topic>General aspects</topic><topic>Heterogeneity</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunosuppressive agents</topic><topic>Infant</topic><topic>Inflammation</topic><topic>Inflammation - 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ravelli, Angelo, Dr</au><au>Martini, Alberto, Prof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Juvenile idiopathic arthritis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2007-03-03</date><risdate>2007</risdate><volume>369</volume><issue>9563</issue><spage>767</spage><epage>778</epage><pages>767-778</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of new drugs that are able to inhibit selectively single molecules or pathways.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>17336654</pmid><doi>10.1016/S0140-6736(07)60363-8</doi><tpages>12</tpages></addata></record> |
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subjects | Adolescent Adults Age Anemia Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antirheumatic agents Arthritis Arthritis, Juvenile - classification Arthritis, Juvenile - diagnosis Arthritis, Juvenile - genetics Arthritis, Juvenile - immunology Arthritis, Juvenile - therapy Biological and medical sciences Bone density Child Child development Child, Preschool Children & youth Chronic Disease Chronic illnesses Classification Diagnosis, Differential Disease control Disease Progression Diseases of the osteoarticular system Drug development Drugs Environmental factors Female Fever General aspects Heterogeneity HLA Antigens - genetics Humans Immune response Immune system Immunosuppressive agents Infant Inflammation Inflammation - immunology Inflammatory joint diseases Injections, Intra-Articular Internal Medicine Joint surgery Laboratories Male Medical sciences Molecular chains Pathogenesis Patients Physical Therapy Modalities Prognosis Psoriasis Rheumatic diseases Rheumatoid arthritis Rheumatology Risk factors Steroids - administration & dosage Treatment Outcome |
title | Juvenile idiopathic arthritis |
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