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Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function?
The aim of our study was to examine long-term effects of nephrocalcinosis in prematurely born children. Preterm neonates (gestational age
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| Published in: | Pediatrics (Evanston) 2007-03, Vol.119 (3), p.468-475 |
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| cites | cdi_FETCH-LOGICAL-c604t-22829e0b7a9397cf71b2534b3028ac57ec0a08e48ec41fea62ec6a6419068d513 |
| container_end_page | 475 |
| container_issue | 3 |
| container_start_page | 468 |
| container_title | Pediatrics (Evanston) |
| container_volume | 119 |
| creator | Kist-van Holthe, Joana E van Zwieten, Paul H.T Schell-Feith, Eveline A Zonderland, Harmien M Holscher, Herma C Wolterbeek, Ron Veen, Sylvia Frolich, Marijke van der Heijden, Bert J |
| description | The aim of our study was to examine long-term effects of nephrocalcinosis in prematurely born children.
Preterm neonates (gestational age |
| doi_str_mv | 10.1542/peds.2006-2639 |
| format | article |
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Preterm neonates (gestational age <32 weeks) with (n = 42) and without (n = 32) nephrocalcinosis were prospectively studied at a mean age of 7.5 (+/-1.0) years.
Blood pressure did not differ in ex-preterm infants with and without nephrocalcinosis but was significantly higher than expected for healthy children. In comparison to healthy children, more ex-preterm infants with neonatal nephrocalcinosis had (mild) chronic renal insufficiency (glomerular filtration rate: <85 mL/min per 1.73 m2; 6 of 40); this is in contrast to ex-preterm infants without neonatal nephrocalcinosis (2 of 32). Tubular phosphate reabsorption and plasma bicarbonate were significantly lower in children with nephrocalcinosis compared with children without nephrocalcinosis. In addition, more ex-preterm infants with and without nephrocalcinosis than expected had low values for plasma bicarbonate and early-morning urine osmolality compared with healthy children. Kidney length of ex-preterm infants with and without nephrocalcinosis was significantly smaller than expected in healthy children of the same height. Nephrocalcinosis persisted long-term in 4 of 42 children but was not related to blood pressure, kidney length, or renal function.
Nephrocalcinosis in preterm neonates can have long-term sequelae for glomerular and tubular function. Furthermore, prematurity per se is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. Long-term follow-up of blood pressure and renal glomerular and tubular function of preterm neonates, especially with neonatal nephrocalcinosis, seems warranted.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2006-2639</identifier><identifier>PMID: 17332199</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Analysis ; Biological and medical sciences ; Blood Pressure ; Calcium - urine ; Care and treatment ; Child ; Child Development ; Children & youth ; Citric Acid - urine ; Clinical outcomes ; Complications and side effects ; Diseases ; Female ; Follow-Up Studies ; General aspects ; Health aspects ; Humans ; Infant, Newborn ; Infant, Premature ; Infants (Premature) ; Kidney - diagnostic imaging ; Kidney - physiology ; Kidney diseases ; Longitudinal Studies ; Lung diseases ; Male ; Medical sciences ; Nephrocalcinosis - complications ; Nephrocalcinosis - physiopathology ; Nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Organ Size ; Pediatrics ; Premature birth ; Premature infants ; Prospective Studies ; Reference Values ; Renal failure ; Renal Insufficiency - etiology ; Renal Insufficiency - urine ; Ultrasonography ; Urinary lithiasis</subject><ispartof>Pediatrics (Evanston), 2007-03, Vol.119 (3), p.468-475</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Mar 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-22829e0b7a9397cf71b2534b3028ac57ec0a08e48ec41fea62ec6a6419068d513</citedby><cites>FETCH-LOGICAL-c604t-22829e0b7a9397cf71b2534b3028ac57ec0a08e48ec41fea62ec6a6419068d513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18565675$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17332199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kist-van Holthe, Joana E</creatorcontrib><creatorcontrib>van Zwieten, Paul H.T</creatorcontrib><creatorcontrib>Schell-Feith, Eveline A</creatorcontrib><creatorcontrib>Zonderland, Harmien M</creatorcontrib><creatorcontrib>Holscher, Herma C</creatorcontrib><creatorcontrib>Wolterbeek, Ron</creatorcontrib><creatorcontrib>Veen, Sylvia</creatorcontrib><creatorcontrib>Frolich, Marijke</creatorcontrib><creatorcontrib>van der Heijden, Bert J</creatorcontrib><title>Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function?</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The aim of our study was to examine long-term effects of nephrocalcinosis in prematurely born children.
Preterm neonates (gestational age <32 weeks) with (n = 42) and without (n = 32) nephrocalcinosis were prospectively studied at a mean age of 7.5 (+/-1.0) years.
Blood pressure did not differ in ex-preterm infants with and without nephrocalcinosis but was significantly higher than expected for healthy children. In comparison to healthy children, more ex-preterm infants with neonatal nephrocalcinosis had (mild) chronic renal insufficiency (glomerular filtration rate: <85 mL/min per 1.73 m2; 6 of 40); this is in contrast to ex-preterm infants without neonatal nephrocalcinosis (2 of 32). Tubular phosphate reabsorption and plasma bicarbonate were significantly lower in children with nephrocalcinosis compared with children without nephrocalcinosis. In addition, more ex-preterm infants with and without nephrocalcinosis than expected had low values for plasma bicarbonate and early-morning urine osmolality compared with healthy children. Kidney length of ex-preterm infants with and without nephrocalcinosis was significantly smaller than expected in healthy children of the same height. Nephrocalcinosis persisted long-term in 4 of 42 children but was not related to blood pressure, kidney length, or renal function.
Nephrocalcinosis in preterm neonates can have long-term sequelae for glomerular and tubular function. Furthermore, prematurity per se is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. Long-term follow-up of blood pressure and renal glomerular and tubular function of preterm neonates, especially with neonatal nephrocalcinosis, seems warranted.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Calcium - urine</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child Development</subject><subject>Children & youth</subject><subject>Citric Acid - urine</subject><subject>Clinical outcomes</subject><subject>Complications and side effects</subject><subject>Diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants (Premature)</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiology</subject><subject>Kidney diseases</subject><subject>Longitudinal Studies</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrocalcinosis - complications</subject><subject>Nephrocalcinosis - physiopathology</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Organ Size</subject><subject>Pediatrics</subject><subject>Premature birth</subject><subject>Premature infants</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Renal failure</subject><subject>Renal Insufficiency - etiology</subject><subject>Renal Insufficiency - urine</subject><subject>Ultrasonography</subject><subject>Urinary lithiasis</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpt0s-L1DAUB_AiijuuXj1KEVzw0PEladPmJOvg_oDBFdFzzKSvnSxpMpu0uP73pu7AuDLkkJB8Xl4I3yx7TWBJqpJ-2GEblxSAF5Qz8SRbEBBNUdK6epotABgpSoDqJHsR4y0AlFVNn2cnpGaMEiEW2c_rmH_B3TZ4raw2zkcTc-PyrwFHDEM6806NGPMrFYZusnnnQ772ri_-Hn-y3rczjnEKmCvX5t_QKZtfTE6PxruPL7NnnbIRX-3n0-zHxefvq6tifXN5vTpfF5pDORaUNlQgbGolmKh1V5MNrVi5YUAbpasaNShosGxQl6RDxSlqrnhJBPCmrQg7zc4e7t0FfzdhHOVgokZrlUM_RVnD3AJEgm__g7d-CunNUSbBmuQgoeIB9cqiNK7zY1C6R4dBWe-wM2n7nHCoBBDRJL884tNocTD6aMH7RwXJjHg_9mqKUTaX68e2OGa1txZ7lOkbVzdHH6ODjzFgJ3fBDCr8lgTknBo5p0bOqZFzalLBm_2XTJsB2wPfxySBd3ugYspJF5TTJh5cU_GK19Wh89b0218m4NzJqDEYHf9ZEiIkkyVv2B8Cdtcy</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Kist-van Holthe, Joana E</creator><creator>van Zwieten, Paul H.T</creator><creator>Schell-Feith, Eveline A</creator><creator>Zonderland, Harmien M</creator><creator>Holscher, Herma C</creator><creator>Wolterbeek, Ron</creator><creator>Veen, Sylvia</creator><creator>Frolich, Marijke</creator><creator>van der Heijden, Bert J</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function?</title><author>Kist-van Holthe, Joana E ; van Zwieten, Paul H.T ; Schell-Feith, Eveline A ; Zonderland, Harmien M ; Holscher, Herma C ; Wolterbeek, Ron ; Veen, Sylvia ; Frolich, Marijke ; van der Heijden, Bert J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-22829e0b7a9397cf71b2534b3028ac57ec0a08e48ec41fea62ec6a6419068d513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Calcium - urine</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child Development</topic><topic>Children & youth</topic><topic>Citric Acid - urine</topic><topic>Clinical outcomes</topic><topic>Complications and side effects</topic><topic>Diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants (Premature)</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiology</topic><topic>Kidney diseases</topic><topic>Longitudinal Studies</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrocalcinosis - complications</topic><topic>Nephrocalcinosis - physiopathology</topic><topic>Nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Organ Size</topic><topic>Pediatrics</topic><topic>Premature birth</topic><topic>Premature infants</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Renal failure</topic><topic>Renal Insufficiency - etiology</topic><topic>Renal Insufficiency - urine</topic><topic>Ultrasonography</topic><topic>Urinary lithiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kist-van Holthe, Joana E</creatorcontrib><creatorcontrib>van Zwieten, Paul H.T</creatorcontrib><creatorcontrib>Schell-Feith, Eveline A</creatorcontrib><creatorcontrib>Zonderland, Harmien M</creatorcontrib><creatorcontrib>Holscher, Herma C</creatorcontrib><creatorcontrib>Wolterbeek, Ron</creatorcontrib><creatorcontrib>Veen, Sylvia</creatorcontrib><creatorcontrib>Frolich, Marijke</creatorcontrib><creatorcontrib>van der Heijden, Bert J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kist-van Holthe, Joana E</au><au>van Zwieten, Paul H.T</au><au>Schell-Feith, Eveline A</au><au>Zonderland, Harmien M</au><au>Holscher, Herma C</au><au>Wolterbeek, Ron</au><au>Veen, Sylvia</au><au>Frolich, Marijke</au><au>van der Heijden, Bert J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function?</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>119</volume><issue>3</issue><spage>468</spage><epage>475</epage><pages>468-475</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The aim of our study was to examine long-term effects of nephrocalcinosis in prematurely born children.
Preterm neonates (gestational age <32 weeks) with (n = 42) and without (n = 32) nephrocalcinosis were prospectively studied at a mean age of 7.5 (+/-1.0) years.
Blood pressure did not differ in ex-preterm infants with and without nephrocalcinosis but was significantly higher than expected for healthy children. In comparison to healthy children, more ex-preterm infants with neonatal nephrocalcinosis had (mild) chronic renal insufficiency (glomerular filtration rate: <85 mL/min per 1.73 m2; 6 of 40); this is in contrast to ex-preterm infants without neonatal nephrocalcinosis (2 of 32). Tubular phosphate reabsorption and plasma bicarbonate were significantly lower in children with nephrocalcinosis compared with children without nephrocalcinosis. In addition, more ex-preterm infants with and without nephrocalcinosis than expected had low values for plasma bicarbonate and early-morning urine osmolality compared with healthy children. Kidney length of ex-preterm infants with and without nephrocalcinosis was significantly smaller than expected in healthy children of the same height. Nephrocalcinosis persisted long-term in 4 of 42 children but was not related to blood pressure, kidney length, or renal function.
Nephrocalcinosis in preterm neonates can have long-term sequelae for glomerular and tubular function. Furthermore, prematurity per se is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. Long-term follow-up of blood pressure and renal glomerular and tubular function of preterm neonates, especially with neonatal nephrocalcinosis, seems warranted.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>17332199</pmid><doi>10.1542/peds.2006-2639</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pediatrics (Evanston), 2007-03, Vol.119 (3), p.468-475 |
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| language | eng |
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| source | Free E-Journal (出版社公開部分のみ） |
| subjects | Analysis Biological and medical sciences Blood Pressure Calcium - urine Care and treatment Child Child Development Children & youth Citric Acid - urine Clinical outcomes Complications and side effects Diseases Female Follow-Up Studies General aspects Health aspects Humans Infant, Newborn Infant, Premature Infants (Premature) Kidney - diagnostic imaging Kidney - physiology Kidney diseases Longitudinal Studies Lung diseases Male Medical sciences Nephrocalcinosis - complications Nephrocalcinosis - physiopathology Nephrology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Organ Size Pediatrics Premature birth Premature infants Prospective Studies Reference Values Renal failure Renal Insufficiency - etiology Renal Insufficiency - urine Ultrasonography Urinary lithiasis |
| title | Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function? |
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