Electrochemotherapy in treatment of tumours

Abstract Aim Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of non-permeant or p...

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Published in:European journal of surgical oncology 2008-02, Vol.34 (2), p.232-240
Main Authors: Sersa, G, Miklavcic, D, Cemazar, M, Rudolf, Z, Pucihar, G, Snoj, M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Bleomycin
Cats
Cisplatin
Cutaneous tumours
Disease Models, Animal
Dogs
Electrochemotherapy
Electrochemotherapy - methods
Electroporation
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Male
Melanoma - drug therapy
Melanoma - pathology
Prospective Studies
Rabbits
Randomized Controlled Trials as Topic
Rats
Risk Assessment
Sensitivity and Specificity
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Surgery
Treatment Outcome
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Summary:Abstract Aim Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of non-permeant or poorly permeant anticancer drugs with high intrinsic cytotoxicity, such as bleomycin or cisplatin, at the site of electric pulse application. Methods An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated. Results In clinical studies electrochemotherapy has proved to be a highly efficient and safe approach for treating cutaneous and subcutaneous tumour nodules. The treatment response for various tumours (predominantly melanoma) was ∼75% complete and 10% partial response of the treated nodules. Conclusions Electrochemotherapy is a new, clinically acknowledged method for the treatment of cutaneous and subcutaneous tumours. Its advantages are high effectiveness on tumours with different histologies, simple application, minimal side effects and the possibility of effective repetitive treatment.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2007.05.016