Influence of E. coli Strain Nissle 1917 (EcN) on Intestinal Gas Dynamics and Abdominal Sensation

E. coli strain Nissle 1917 (EcN) is a probiotic clinically used with various indications. However, especially at the beginning of treatment, some patients report abdominal bloating. In a prospective, randomized, double-blind study in 30 healthy individuals we assessed the influences of EcN on intest...

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Bibliographic Details
Published in:Digestive diseases and sciences 2008-02, Vol.53 (2), p.443-450
Main Authors: Hernando-Harder, Ana Cristina, von Bünau, Rudolf, Nadarajah, Mahaluxmy, Singer, Manfred Vincenz, Harder, Hermann
Format: Article
Language:English
Subjects:
Abdomen - physiology
Adult
Biochemistry
Biological and medical sciences
Defecation - physiology
Diet
Double-Blind Method
Escherichia coli
Escherichia coli - classification
Female
Flatulence - epidemiology
Gases
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Transit - physiology
Hepatology
Humans
Intestines - physiology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Other diseases. Semiology
Probiotics - administration & dosage
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transplant Surgery
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Summary:E. coli strain Nissle 1917 (EcN) is a probiotic clinically used with various indications. However, especially at the beginning of treatment, some patients report abdominal bloating. In a prospective, randomized, double-blind study in 30 healthy individuals we assessed the influences of EcN on intestinal gas dynamics and abdominal sensation. After one week without medication volunteers orally received 2.5–25 × 10 9 colony-forming units of EcN or placebo per day for 21 days. EcN was well tolerated and did not significantly affect abdominal symptoms, stool frequency or stool consistency. During gas challenge at different days no difference in the perception scores (range from 0 = no perception to 6 = pain) was observed between the two groups: the mean perception score was 1.2 (SD 0.2) in the EcN group and 1.4 (SD 0.2) in the placebo group. EcN had no relevant influence on intestinal gas dynamics.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-007-9892-3