MicroParticle photophysics illuminates viral bio-sensing

The authors present an approach for specific and rapid unlabeled detection of a virus by using a microsphere-based whispering gallery mode sensor that transduces the interaction of a whole virus with an anchored antibody. They show theoretically that this sensor can detect a single virion below the...

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Bibliographic Details
Published in:Faraday discussions 2008-01, Vol.137, p.65-83
Main Authors: Arnold, S, Ramjit, R, Keng, D, Kolchenko, V, Teraoka, I
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
HIV - isolation & purification
Humans
Light
Microfluidic Analytical Techniques - methods
Virion - isolation & purification
Viruses - isolation & purification
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Summary:The authors present an approach for specific and rapid unlabeled detection of a virus by using a microsphere-based whispering gallery mode sensor that transduces the interaction of a whole virus with an anchored antibody. They show theoretically that this sensor can detect a single virion below the mass of HIV. A micro-fluidic device is presented that enables the discrimination between viruses of similar size and shape.
ISSN:1359-6640
1364-5498
DOI:10.1039/b702920a