Molecular biology: the expanding world of small RNAs

Molecular cell biology has long been dominated by a protein-centric view. But the emergence of small, non-coding RNAs challenges this perception. These plentiful RNAs regulate gene expression at different levels, and have essential roles in health and disease.

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Bibliographic Details
Published in:Nature (London) 2008-01, Vol.451 (7177), p.414-416
Main Authors: Grosshans, Helge, Filipowicz, Witold
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Cellular biology
Discovery and exploration
Gene expression
Genetic aspects
History, 20th Century
History, 21st Century
Humans
Identification and classification
Models, Genetic
Molecular biology
Molecular Biology - history
Organ Specificity
Properties
Protein Biosynthesis
Proteins
Ribonucleic acid
RNA
RNA Interference
RNA, Double-Stranded - biosynthesis
RNA, Double-Stranded - genetics
RNA, Double-Stranded - metabolism
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Untranslated - biosynthesis
RNA, Untranslated - classification
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Species Specificity
Substrate Specificity
Viruses - genetics
Viruses - immunology
Online Access:Get full text
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Description
Summary:Molecular cell biology has long been dominated by a protein-centric view. But the emergence of small, non-coding RNAs challenges this perception. These plentiful RNAs regulate gene expression at different levels, and have essential roles in health and disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/451414a