Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis

Acquired abnormalities of coagulation and fibrinolysis in nephrotic syndrome have been implicated in the pathogenesis of deep-vein and arterial thrombosis. A mutation in the factor V and methylenetetrahydrofolate reductase (MTHFR) gene, the commonest inherited risk factor for venous thrombosis, may...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2008-03, Vol.23 (3), p.491-494
Main Authors: Büyükçelik, Mithat, Karakök, Metin, Başpınar, Osman, Balat, Ayşe
Format: Article
Language:English
Subjects:
Adolescent
Brief Report
Factor V - genetics
Female
Glomerulonephritis, Membranous - complications
Glomerulonephritis, Membranous - genetics
Humans
Medicine
Medicine & Public Health
Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics
Mutation
Nephrology
Pediatrics
Thrombosis - complications
Thrombosis - genetics
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acquired abnormalities of coagulation and fibrinolysis in nephrotic syndrome have been implicated in the pathogenesis of deep-vein and arterial thrombosis. A mutation in the factor V and methylenetetrahydrofolate reductase (MTHFR) gene, the commonest inherited risk factor for venous thrombosis, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome. Here, we report on an arterial thrombosis in a young girl with idiopathic membranous glomerulonephritis associated with heterozygous factor V Leiden and homozygous MTHFR C677T mutation. We postulate that screening for factors such as factor V Leiden and MTHFR C677T mutation may be beneficial to patients associated with thromboembolism and idiopathic nephrotic syndrome.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-007-0657-1