Apolipoprotein B mRNA—Editing Enzyme, Catalytic Polypeptide—Like 3G: A Possible Role in the Resistance to HIV of HIV-Exposed Seronegative Individuals

Apolipoprotein B mRNA—editing enzyme, catalytic polypeptide—like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIVexposed serone...

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Bibliographic Details
Published in:The Journal of infectious diseases 2007-04, Vol.195 (7), p.960-964
Main Authors: Biasin, Mara, Piacentini, Luca, Lo Caputo, Sergio, Kanari, Yasuyoshi, Magri, Guiliana, Trabattoni, Daria, Naddeo, Valentina, Lopalco, Lucia, Clivio, Alberto, Cesana, Eugenio, Fasano, Francesca, Bergamaschi, Cristina, Mazzotta, Francesco, Miyazawa, Masaaki, Clerici, Mario
Format: Article
Language:English
Subjects:
AIDS
APOBEC-1 Deaminase
Biological and medical sciences
Biopsies
Case-Control Studies
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Enzymes
Female
Fundamental and applied biological sciences. Psychology
HIV
HIV 1
HIV infections
HIV Infections - blood
HIV Infections - virology
HIV Seropositivity
HIV-1 - pathogenicity
HIV-1 - physiology
HIV/AIDS
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Leukocytes, Mononuclear - metabolism
Medical sciences
Messenger RNA
Microbiology
Miscellaneous
Monocytes
RNA Editing
RNA, Messenger - analysis
Virology
Virus Replication - physiology
Viruses
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Summary:Apolipoprotein B mRNA—editing enzyme, catalytic polypeptide—like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIVexposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)—mainly CD14+ cells—and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/511988