Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

Summary This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the issues associated with the treatment of hospital infections caused by Gram-negative bacteria. The group discussed the severe clinical problems...

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Bibliographic Details
Published in:The Lancet infectious diseases 2008-02, Vol.8 (2), p.133-139
Main Authors: Chopra, Ian, Prof, Schofield, Christopher, Prof, Everett, Martin, PhD, O'Neill, Alex, PhD, Miller, Keith, PhD, Wilcox, Mark, Prof, Frère, Jean-Marie, Prof, Dawson, Mike, PhD, Czaplewski, Lloyd, PhD, Urleb, Uros, PhD, Courvalin, Patrice, Prof
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic resistance
Bacteria
Biological and medical sciences
Cross Infection - drug therapy
Drug Design
Drug Resistance, Bacterial
General aspects
Gram-Negative Bacteria - drug effects
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Human infectious diseases. Experimental studies and models
Humans
Infectious Disease
Infectious diseases
Medical sciences
Pharmaceutical industry
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Summary:Summary This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the issues associated with the treatment of hospital infections caused by Gram-negative bacteria. The group discussed the severe clinical problems arising from the emergence of antibiotic resistance in these bacteria and the lack of new antibacterial agents to challenge the threat. The discovery of new drugs active against hospital-acquired Gram-negative bacteria is essential to prevent a future medical and social catastrophe. An important strategy to promote drug discovery will be the development of focused cooperations between academic institutions and small pharmaceutical companies.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(08)70018-5