Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T

Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T Evangelos Giannitsis, Henning Steen, Kerstin Kurz, Boris Ivandic, Anke C. Simon, Simon Futterer, Christian Schild, Peter Isfort, Allan S....

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2008-01, Vol.51 (3), p.307-314
Main Authors: Giannitsis, Evangelos, MD, Steen, Henning, MD, Kurz, Kerstin, MD, Ivandic, Boris, MD, Simon, Anke C., MD, Futterer, Simon, MD, Schild, Christian, MD, Isfort, Peter, MD, Jaffe, Allan S., MD, FACC, Katus, Hugo A., MD, FACC
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology
Cardiology. Vascular system
Cardiovascular
Coronary Angiography
Coronary vessels
Electrocardiography
Female
Heart attacks
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multivariate Analysis
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - pathology
Myocardium - pathology
NMR
Nuclear magnetic resonance
ROC Curve
Statistics, Nonparametric
Troponin T - blood
Ventricular Function, Left
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Summary:Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T Evangelos Giannitsis, Henning Steen, Kerstin Kurz, Boris Ivandic, Anke C. Simon, Simon Futterer, Christian Schild, Peter Isfort, Allan S. Jaffe, Hugo A. Katus We compared single-point versus serial cardiac troponin T (cTnT) measurements after acute myocardial infarction in 61 patients. Single-point, peak, and integrated area under the curve (AUC) cTnT values were plotted against contrast-enhanced magnetic resonance imaging infarct mass. Except for admission cTnT, all single-point values on any of the first 4 days, peak-cTnT and AUC cTnT correlated comparably well with infarct mass. Day-4 cTnT showed the highest correlation and performed similarly to peak-cTnT or AUC cTnT. All single-point cTnTs, except admission-cTnTs, give a good estimation of infarct size and performed as well as peak-cTnT or AUC cTnT. Particularly, Day-4 cTnT may gain clinical acceptance because the measurement is easy and inexpensive.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.09.041