Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T

• Published in: Journal of the American College of Cardiology 2008-01, Vol.51 (3), p.307-314
• Main Authors: Giannitsis, Evangelos, MD, Steen, Henning, MD, Kurz, Kerstin, MD, Ivandic, Boris, MD, Simon, Anke C., MD, Futterer, Simon, MD, Schild, Christian, MD, Isfort, Peter, MD, Jaffe, Allan S., MD, FACC, Katus, Hugo A., MD, FACC
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Biomarkers - blood; Cardiology; Cardiology. Vascular system; Cardiovascular; Coronary Angiography; Coronary vessels; Electrocardiography; Female; Heart attacks; Humans; Internal Medicine; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Multivariate Analysis; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - pathology; Myocardium - pathology; NMR; Nuclear magnetic resonance; ROC Curve; Statistics, Nonparametric; Troponin T - blood; Ventricular Function, Left
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.09.041

Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T Evangelos Giannitsis, Henning Steen, Kerstin Kurz, Boris Ivandic, Anke C. Simon, Simon Futterer, Christian Schild, Peter Isfort, Allan S. Jaffe, Hugo A. Katus We compared single-point versus serial cardiac troponin T (cTnT) measurements after acute myocardial infarction in 61 patients. Single-point, peak, and integrated area under the curve (AUC) cTnT values were plotted against contrast-enhanced magnetic resonance imaging infarct mass. Except for admission cTnT, all single-point values on any of the first 4 days, peak-cTnT and AUC cTnT correlated comparably well with infarct mass. Day-4 cTnT showed the highest correlation and performed similarly to peak-cTnT or AUC cTnT. All single-point cTnTs, except admission-cTnTs, give a good estimation of infarct size and performed as well as peak-cTnT or AUC cTnT. Particularly, Day-4 cTnT may gain clinical acceptance because the measurement is easy and inexpensive.