Association between folate‐metabolizing pathway polymorphism and non‐Hodgkin lymphoma

• Published in: British journal of haematology 2008-02, Vol.140 (3), p.287-294
• Main Authors: Kim, Hee Nam, Lee, Il‐Kwon, Kim, Yeo‐Kyeoung, Tran, Huong Thi Thanh, Yang, Deok‐Hwan, Lee, Je‐Jung, Shin, Min–Ho, Park, Kyeong‐Soo, Shin, Myung‐Geun, Choi, Jin‐Su, Kim, Hyeoung‐Joon
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Case-Control Studies; Female; Ferredoxin-NADP Reductase - genetics; Folic Acid - metabolism; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large B-Cell, Diffuse - enzymology; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Non-Hodgkin - enzymology; Lymphoma, Non-Hodgkin - genetics; Lymphoma, T-Cell - enzymology; Lymphoma, T-Cell - genetics; Male; Medical sciences; methionine synthase reductase; methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; non‐Hodgkin lymphoma; Odds Ratio; polymorphism; Polymorphism, Genetic; Risk; thymidylate synthase; Thymidylate Synthase - genetics
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.2007.06893.x

Summary Polymorphisms in the genes coding folate‐metabolizing enzymes affect the risk of some forms of cancer. We investigated the association between these polymorphisms and non‐Hodgkin lymphoma (NHL) risk in a population‐based study (583 cases and 1700 controls). The MTHFR 677TT and CT genotypes were associated with reduced risk for NHL [odds ratios (OR) = 0·79; 95% confidence intervals (CI) = 0·65–0·98 for 677CT and 0·61; 0·45–0·82 for 677TT] and diffuse large B‐cell lymphoma (DLBCL) (OR = 0·68; 0·51–0·88 for 677CT; OR = 0·56; 0·38–0·83 for 677TT). The MTHFR 1298CC genotype was associated with increased risk for NHL (OR = 1·71; 1·07–2·75) and T‐cell lymphoma (OR = 3·05; 1·53‐6·11). The MTRR 66GG genotype was associated with increased risk for DLBCL (OR = 1·56; 1·03‐2·38) and the TYMS 2R2R genotype was associated with increased risk for T‐cell lymphoma (OR = 2·83; 1·33–6·01). Using subjects with 3RG3RG as a reference group, TYMS 2R2R was associated with increased risk for T‐cell lymphoma (OR = 2·46; 1·04–5·79). Interestingly, we observed a reduced association between the TYMS 2R3RG genotype and DLBCL (OR = 0·61; 0·38–0·99). These results suggest that MTHFR, MTRR and TYMS polymorphisms may play a significant role in the risk for NHL.