Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT

The diagnostic accuracy of screening for bone metastases was evaluated using whole-body magnetic resonance imaging (WB-MRI) compared with combined fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) (FDG-PET-CT). In a prospective, blinded study, 30 consecutive pa...

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Bibliographic Details
Published in:European radiology 2007-04, Vol.17 (4), p.939-949
Main Authors: Schmidt, Gerwin P, Schoenberg, Stefan O, Schmid, Rupert, Stahl, Robert, Tiling, Reinhold, Becker, Christoph R, Reiser, Maximilian F, Baur-Melnyk, Andrea
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Bone diseases
Bone imaging
Bone lesions
Bone marrow
Bone Neoplasms - diagnosis
Bone Neoplasms - secondary
Computed tomography
Diagnostic Errors
Diagnostic systems
Emissions
Female
Field of view
Follow-Up Studies
Humans
Lesions
Magnetic Resonance Imaging
Male
Medical imaging
Metastases
Metastasis
Middle Aged
Neoplasm Metastasis - diagnosis
Neoplasm Staging
Nuclear medicine
Patients
Pelvis
Positron emission
Positron emission tomography
Predictive Value of Tests
Sensitivity and Specificity
Spatial discrimination
Spatial resolution
Spine
Thorax
Tomography
Tomography, X-Ray Computed
Whole Body Imaging
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Summary:The diagnostic accuracy of screening for bone metastases was evaluated using whole-body magnetic resonance imaging (WB-MRI) compared with combined fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) (FDG-PET-CT). In a prospective, blinded study, 30 consecutive patients (18 female, 12 male; 24-76 years) with different oncological diseases and suspected skeletal metastases underwent FDG-PET-CT as well as WB-MRI with the use of parallel imaging (PAT). With a 32-channel scanner, coronal imaging of the entire body and sagittal imaging of the complete spine was performed using T1-weighted and short tau inversion recovery (STIR) sequences in combination. PET-CT was conducted using a low-dose CT for attenuation correction, a PET-emission scan and diagnostic contrast-enhanced CT scan covering the thorax, abdomen and pelvis. Two radiologists read the MRI scans, another radiologist in combination with a nuclear medicine physician read the PET-CT scans, each in consensus. The standard of reference was constituted by radiological follow-up within at least 6 months. In 28 patients, 102 malignant and 25 benign bone lesions were detected and confirmed. WB-MRI showed a sensitivity of 94% (96/102), PET-CT exams achieved 78% (79/102; P0.05). Diagnostic accuracy was 91% (115/127) and 78% (99/127; P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-006-0361-8